Seroprevalence of SARS-CoV-2 IgG specific antibodies among healthcare workers in the Northern Metropolitan Area of Barcelona, Spain, after the first pandemic wave

被引:27
作者
Barallat, Jaume [1 ]
Fernandez-Rivas, Gema [2 ,3 ]
Quirant-Sanchez, Bibiana [4 ,5 ]
Gonzalez, Victoria [2 ,6 ,7 ]
Dolade, Maria [1 ]
Martinez-Caceres, Eva [4 ,5 ]
Pina, Monica [8 ]
Matllo, Joan [9 ]
Estrada, Oriol [10 ]
Blanco, Ignacio [11 ,12 ]
机构
[1] Inst Catala Salut, Gerencia Terr Metropolitana Nord, Lab Clin Metropolitana Nord, Serv Anal Clin & Bioquim, Barcelona, Spain
[2] Inst Catala Salut, Gerencia Terr Metropolitana Nord, Lab Clin Metropolitana Nord, Serv Microbiol, Barcelona, Spain
[3] Univ Autonoma Barcelona, Dept Genet & Microbiol, Barcelona, Spain
[4] Inst Catala Salut, Gerencia Terr Metropolitana Nord, Lab Clin Metropolitana Nord, Serv Immunol, Barcelona, Spain
[5] Univ Autonoma Barcelona, Dept Biol Celular Fisiol & Immunol, Barcelona, Spain
[6] Generalitat Catalunya, Dept Salut, Ctr Estudis Epidemiol Infecc Transmissio Sexual &, Badalona, Spain
[7] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain
[8] Inst Catala Salut, Gerencia Terr Metropolitana Nord, Unitat Basica Prevencio, Direccio Atencio Primaria, Barcelona, Spain
[9] Hosp Badalona Germans Trias & Pujol, Inst Catala Salut, Gerencia Terr Metropolitana Nord, Unitat Basica Prevencio, Barcelona, Spain
[10] Inst Catala Salut, Gerencia Terr Metropolitana Nord, Direccio Innovacio & Proc Transversals, Barcelona, Spain
[11] Inst Catala Salut, Gerencia Terr Metropolitana Nord, Lab Clin Metropolitana Nord, Serv Genet Clin, Barcelona, Spain
[12] Univ Autonoma Barcelona, Dept Cirurgia, Barcelona, Spain
关键词
D O I
10.1371/journal.pone.0244348
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background The rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) around the world has caused a global pandemic, infecting millions of individuals, with an unprecedented impact in health care systems worldwide. Healthcare workers are one of the risk groups that need to be well protected, due to their strategic role in patient management, presently and in prevention of healthcare needs for future outbreaks. Here, we present the results of the first SARS-CoV-2 seroprevalence study in the Northern Metropolitan Area of Barcelona, Spain. Methods IgG SARS-CoV-2 antibodies were analyzed in serum samples from 7563 healthcare workers of the Northern Metropolitan Area of Barcelona. Samples were collected after the first pandemic wave (from May 4th to May 22nd, 2020) and were analyzed by automated chemiluminescence assays. All samples were tested for IgG anti-S1/S2. Participant samples with negative or equivocal results but with analytical signals above the limit of detection and/or previously confirmed COVID-19 diagnosis were also tested for IgG anti-Nucleocapsid. Results A total of 779 of 7563 (10.3%) healthcare workers were positive for anti-SARS-CoV-2 IgG (specific for either S1/S2 or N antigens). No significant differences were observed between those working at primary care or at the reference hospital. Interestingly, among 341 participants with a confirmed COVID-19 diagnosis, 36 (10.55%) tested negative for SARS-CoV-2 IgG (both S1/S2 and recombinant N antigen). Conclusion Seroprevalence of anti-SARS-CoV-2 IgG in the healthcare workers of the North Metropolitan Area of Barcelona was higher than in the general population in the same geographical area. Safety measures have to be stressed in order to protect these essential workers from future pandemic waves.
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