Rearrangement and degradation of cephalosporins and penicillins in the presence of mercury(II) trifluoroacetate

被引：7
作者：
Gunda, TE [1 ]
机构：
[1] Hungarian Acad Sci, Antibiot Res Grp, H-4010 Debrecen, Hungary
来源：
ORGANIC LETTERS | 2000年 / 2卷 / 02期
关键词：
D O I：
10.1021/ol9911627
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Cephalosporins and penicillins rearrange under the influence of mercury(ll) trifluoroacetate in methanol to non-beta-lactam products. The mechanisms of the rearrangements are different in the two cases. Whereas the open chain aminoacrylic acid derivative 4 is produced from cephalosporins, the oxazole 7 and the propionamide 6 derivatives are the products from penicillins.
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页码：103 / 105
页数：3
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