Endogenous H2S-Triggered In Situ Synthesis of NIR-II-Emitting Nanoprobe for In Vivo Intelligently Lighting Up Colorectal Cancer

被引：37

作者：

Deng, Zhiming ^{[1
,2
]}

Jiang, Mingyang ^{[1
,2
]}

Li, Youbin ^{[1
,2
]}

Liu, Hongrong ^{[1
,2
]}

Zeng, Songjun ^{[1
,2
]}

Hao, Jianhua ^{[3
]}

机构：

[1] Hunan Normal Univ, Sch Phys & Elect, Changsha 410081, Hunan, Peoples R China

[2] Hunan Normal Univ, Key Lab Low Dimens Quantum Struct & Quantum Contr, Minist Educ, Synerget Innovat Ctr Quantum Effects & Applicat, Changsha 410081, Hunan, Peoples R China

[3] Hong Kong Polytech Univ, Dept Appl Phys, Hong Kong, Peoples R China

来源：

ISCIENCE | 2019年 / 17卷

基金：

中国国家自然科学基金;

关键词：

AG2S QUANTUM DOTS; HYDROGEN-SULFIDE; SILVER NANOPARTICLES; FLUORESCENT-PROBES; THERAPY; PROTEIN; NANOMATERIALS; BIOSYNTHESIS; FLUOROPHORES; CELLS;

D O I：

10.1016/j.isci.2019.06.034

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Overexpression of endogenous H2S is one of the key characteristic in colon cancer. However, developing endogenous H2S-activated optical probes for specific diagnosis of colorectal cancer is rarely explored. Herein, an in situ H2S-activatable second near-infrared (NIR-II)-emitting nanoprobe based on Ag-chicken egg white (Ag-CEW) complex for intelligently lighting up colorectal cancer was explored. The designed Ag-CEW complex holds efficient NIR-II emission of 1,000-1,400 nm via endogenous H2S-induced in situ chemical reaction to form Ag2S quantum dots (QDs). After reaction, the designed Ag-CEW complex with high photo-stability and biocompatibility was successfully used for NIR-II imaging-guided specific visualization and precise location of colorectal cancer via endogenous H2S activation. Therefore, our findings provide a new route for specifically targeting diagnosis of colon cancer based on the in situ-activatable NIR-II probe.

引用

页码：217 / +

页数：27

共 57 条

[1] The In Situ Sulfidation of Cu2O by Endogenous H2S for Colon Cancer Theranostics [J].

An, Lu ;

Wang, Xiaodong ;

Rui, Xichuan ;

Lin, Jiaomin ;

Yang, Hong ;

Tian, Qiwei ;

Tao, Cheng ;

Yang, Shiping .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 57 (48) :15782-15786

[2]

Antaris AL, 2016, NAT MATER, V15, P235, DOI [10.1038/NMAT4476, 10.1038/nmat4476]

[3] Next-generation in vivo optical imaging with short-wave infrared quantum dots [J].

Bruns, Oliver T. ;

Bischof, Thomas S. ;

Harris, Daniel K. ;

Franke, Daniel ;

Shi, Yanxiang ;

Riedemann, Lars ;

Bartelt, Alexander ;

Jaworski, Frank B. ;

Carr, Jessica A. ;

Rowlands, Christopher J. ;

Wilson, Mark W. B. ;

Chen, Ou ;

Wei, He ;

Hwang, Gyu Weon ;

Montana, Daniel M. ;

Coropceanu, Igor ;

Achorn, Odin B. ;

Kloepper, Jonas ;

Heeren, Joerg ;

So, Peter T. C. ;

Fukumura, Dai ;

Jensen, Klavs F. ;

Jain, Rakesh K. ;

Bawendi, Moungi G. .

NATURE BIOMEDICAL ENGINEERING, 2017, 1 (04)

[4] In Situ Biosynthesis of Fluorescent Platinum Nanoclusters: Toward Self-Bioimaging-Guided Cancer Theranostics [J].

Chen, Donghua ;

Zhao, Chunqiu ;

Ye, Jing ;

Li, Qiwei ;

Liu, Xiaoli ;

Su, Meina ;

Jiang, Hui ;

Amatore, Christian ;

Selke, Matthias ;

Wang, Xuemei .

ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (32) :18163-18169

[5] Drug-Induced Self-Assembly of Modified Albumins as Nano-theranostics for Tumor-Targeted Combination Therapy [J].

Chen, Qian ;

Wang, Xin ;

Wang, Chao ;

Feng, Liangzhu ;

Li, Yonggang ;

Liu, Zhuang .

ACS NANO, 2015, 9 (05) :5223-5233

[6] An Imagable and Photothermal "Abraxane-Like" Nanodrug for Combination Cancer Therapy to Treat Subcutaneous and Metastatic Breast Tumors [J].

Chen, Qian ;

Liang, Chao ;

Wang, Chao ;

Liu, Zhuang .

ADVANCED MATERIALS, 2015, 27 (05) :903-910

[7] A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria [J].

Chen, Yuncong ;

Zhu, Chengcheng ;

Yang, Zhenghao ;

Chen, Junjie ;

He, Yafeng ;

Jiao, Yang ;

He, Weijiang ;

Qiu, Lin ;

Cen, Jiajie ;

Guo, Zijian .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (06) :1688-1691

[8] Silver as Antibacterial Agent: Ion, Nanoparticle, and Metal [J].

Chernousova, Svitlana ;

Epple, Matthias .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, 52 (06) :1636-1653

[9] Reduced Cytotoxicity of Graphene Nanosheets Mediated by Blood-Protein Coating [J].

Chong, Yu ;

Ge, Cuicui ;

Yang, Zaixing ;

Garate, Jose Antonio ;

Gu, Zonglin ;

Weber, Jeffrey K. ;

Liu, Jiajia ;

Zhou, Ruhong .

ACS NANO, 2015, 9 (06) :5713-5724

[10] Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer [J].

Dang, Xiangnan ;

Gu, Li ;

Qi, Jifa ;

Correa, Santiago ;

Zhang, Geran ;

Belcher, Angela M. ;

Hammond, Paula T. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (19) :5179-5184

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