A physical map of the mouse genome

被引：232

作者：

Gregory, SG

Sekhon, M

Schein, J

Zhao, SY

Osoegawa, K

Scott, CE

Evans, RS

Burridge, PW

Cox, TV

Fox, CA

Hutton, RD

Mullenger, IR

Phillips, KJ

Smith, J

Stalker, J

Threadgold, GJ

Birney, E

Wylie, K

Chinwalla, A

Wallis, J

Hillier, L

Carter, J

Gaige, T

Jaeger, S

Kremitzki, C

Layman, D

Maas, J

McGrane, R

Mead, K

Walker, R

Jones, S

Smith, M

Asano, J

Bosdet, I

Chan, S

Chittaranjan, S

Chiu, R

Fjell, C

Fuhrmann, D

Girn, N

Gray, C

Guin, R

Hsiao, L

Krzywinski, M

Kutsche, R

Lee, SS

Mathewson, C

McLeavy, C

Messervier, S

Ness, S

机构：

[1] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[2] Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA

[3] British Columbia Canc Agcy, Genome Sci Ctr, Vancouver, BC V5Z 4E6, Canada

[4] Inst Genom Res, Rockville, MD 20850 USA

[5] Childrens Hosp, Oakland Res Inst, Oakland, CA 94609 USA

[6] EMBL European Bioinformat Inst, Cambridge CB10 1SD, England

[7] Washington Univ, Dept Elect Engn, St Louis, MO 63130 USA

来源：

NATURE | 2002年 / 418卷 / 6899期

关键词：

D O I：

10.1038/nature00957

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A physical map of a genome is an essential guide for navigation, allowing the location of any gene or other landmark in the chromosomal DNA. We have constructed a physical map of the mouse genome that contains 296 contigs of overlapping bacterial clones and 16,992 unique markers. The mouse contigs were aligned to the human genome sequence on the basis of 51,486 homology matches, thus enabling use of the conserved synteny (correspondence between chromosome blocks) of the two genomes to accelerate construction of the mouse map. The map provides a framework for assembly of whole-genome shotgun sequence data, and a tile path of clones for generation of the reference sequence. Definition of the human-mouse alignment at this level of resolution enables identification of a mouse clone that corresponds to almost any position in the human genome. The human sequence may be used to facilitate construction of other mammalian genome maps using the same strategy.

引用

页码：743 / U3

页数：11

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