Glycogenosis type I and diabetes mellitus: a common mechanism for renal dysfunction?

被引:17
作者
Mundy, HR [1 ]
Lee, PJ [1 ]
机构
[1] UCL Natl Hosp Neurol, Charles Dent Metab Unit, London WC1N 3BG, England
关键词
D O I
10.1016/S0306-9877(02)00199-8
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Diabetes mellitus and glycogen storage disease type I (GSDI) may initially appear disparate in metabolic profile: one characterized by uncontrolled hyperglycaemia due to disturbed insulin function and the other by fasting hypoglycaemia caused by impaired gluconeogenesis and glycogenolysis. However, they share a remarkably similar pattern and progression of renal dysfunction. This may be, we suggest, due to a convergence of their metabolic sequelae in upregulation of flux through the pentose phosphate pathway. This pathway yields triose phosphate molecules, which are precursors of the lipid, diacylglycerol (DAG). DAG plays an important role in the intrarenal renin-angiotensin system via the protein kinase C pathway. GSDI may be an interesting model which helps to unravel further the contributions of the many, varied nephropathic influences in diabetes. Conversely patients with this rare disorders would have much to gain from the innovative and vastly greater body of research carried out in diabetes. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:110 / 114
页数:5
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