Biphasic magnetic nanoparticles-nanovesicle hybrids for chemotherapy and self-controlled hyperthermia

Aim: The aim was to develop magnetic nanovesicles for chemotherapy and self-controlled hyperthermia that prevent overheating of tissues. Materials & methods: Magnetic nanovesicles containing paclitaxel and a dextran-coated biphasic suspension of La0.75Sr0.25MnO3 and Fe3O4 nanoparticles (magnetic nanoparticles) were developed. Results: Encapsulation efficiencies of magnetic nanoparticles and paclitaxel were 67 +/- 5 and 83 +/- 3%, respectively. Sequential release performed at 37 degrees C for 1 h followed by 44 degrees C for another 1 h (as expected for intratumoral injection), showed a cumulative release of 6.6% (109.6 mu g), which was above the IC50 of the drug. In an alternating current magnetic field, the temperature remained controlled at 44 degrees C and a synergistic cytotoxicity of paclitaxel and hyperthermia was observed in MCF-7 cells. Conclusion: Magnetic nanovesicles containing biphasic suspensions La0.75Sr0.25MnO3 and Fe3O4 nanoparticles encapsulating paclitaxel have potential for combined self-controlled hyperthermia and chemotherapy.