Emergence of Multidrug-Resistant Influenza A(H1N1)pdm09 Virus Variants in an Immunocompromised Child Treated With Oseltamivir and Zanamivir

被引：51

作者：

Tamura, Daisuke ^{[1
]}

DeBiasi, Roberta L. ^{[2
,4
,5
]}

Okomo-Adhiambo, Margaret ^{[1
]}

Mishin, Vasiliy P. ^{[1
]}

Campbell, Angela P. ^{[1
]}

Loechelt, Brett ^{[3
,4
]}

Wiedermann, Bernhard L. ^{[2
,4
]}

Fry, Alicia M. ^{[1
]}

Gubareva, Larisa V. ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Natl Ctr Immunizat & Resp, Influenza Div, Atlanta, GA USA

[2] George Washington Univ, Sch Med, Div Pediat Infect Dis, Washington, DC USA

[3] George Washington Univ, Sch Med, Childrens Natl Med Ctr, Div Blood & Marrow Transplantat, Washington, DC USA

[4] George Washington Univ, Sch Med, Dept Pediat, Washington, DC USA

[5] George Washington Univ, Sch Med, Div Microbiol, Div Immunol & Trop Med, Washington, DC USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2015年 / 212卷 / 08期

关键词：

neuraminidase; drug resistance; pyrosequencing; oseltamivir; zanamivir; NEURAMINIDASE INHIBITORS; A H1N1; MUTATIONS; RECOVERY;

D O I：

10.1093/infdis/jiv245

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Prolonged treatment of an immunocompromised child with oseltamivir and zanamivir for A(H1N1) pdm09 virus infection led to the emergence of viruses carrying H275Y and/or E119G in the neuraminidase (NA). When phenotypically evaluated by NA inhibition, the dual H275Y-E119G substitution caused highly reduced inhibition by 4 NA inhibitors: oseltamivir, zanamivir, peramivir, and laninamivir.

引用

页码：1209 / 1213

页数：5

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