Could clomiphene kindle acute manic episode in a male patient? A case report

被引：4

作者：

Sinha, Pallavi ^{[1
]}

Garg, Amit ^{[1
]}

机构：

[1] IHBAS, Dept Psychiat, Delhi 110095, India

来源：

GENERAL HOSPITAL PSYCHIATRY | 2014年 / 36卷 / 05期

关键词：

Clomiphene; Manic episode; Male; Bipolar disorder; TESTOSTERONE; CITRATE; MOOD; MEN;

D O I：

10.1016/j.genhosppsych.2014.05.011

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Psychiatric adverse effects associated with the use of clomiphene are relatively uncommon. Though case reports link mood swings to be associated with clomiphene, it is not known to be associated with a syndromal affective episode. Being a selective estrogen receptor modulator, clomiphene affects the hypothalamus-pituitary-gonadal axis and can have potential neuropsychiatric effects in vulnerable persons. Herein we report a case of clomiphene-induced manic episode in a known bipolar male patient. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：549.e5 / 549.e6

页数：2

共 15 条

[1]

Blenner J L, 1991, J Obstet Gynecol Neonatal Nurs, V20, P321, DOI 10.1111/j.1552-6909.1991.tb01695.x

[2]

Blum M, 1989, Clin Exp Obstet Gynecol, V16, P9

[3] Extracellular Signal-Regulated Kinase 2 Signaling in the Hippocampal Dentate Gyrus Mediates the Antidepressant Effects of Testosterone [J].