The tumoral stroma, a breeding ground for cancer cells

被引：9
作者：
Buache, Emilie
Rio, Marie-Christine [1 ]
机构：
[1] IGBMC, Dept Genom Fonct & Canc, F-67404 Illkirch Graffenstaden, France
来源：
M S-MEDECINE SCIENCES | 2014年 / 30卷 / 04期
关键词：
CARCINOMA-ASSOCIATED FIBROBLASTS; BREAST-CANCER; EXTRACELLULAR-MATRIX; MICROENVIRONMENT; PROGRESSION; STROMELYSIN-3; INVASION; METALLOPROTEINASES; METASTASIS; ADIPOCYTES;
D O I：
10.1051/medsci/20143004011
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Carcinomas are constituted by malignant epithelial cells and the tumor microenvironment also called tumoral stroma. The present non-exhaustive review will focus on cellular and molecular key events implicating cancer-associated fibroblasts (CAF) and the extracellular matrix (ECM) in the stroma remodeling processes occuring during tumor invasive steps. We will also discuss the place of the stroma in the cancerology today, the recent progresses done and its usefulness to design new therapies.
引用
收藏
页码：385 / 390
页数：6
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