Development of Green protocols for the synthesis of 1H-benzo[d]imidazolo aryl amide derivatives and evaluation of their biological activity

被引：0
|
作者：
Laxminarayana, E. [1 ]
Reddy, B. Srinivasa [2 ]
Reddy, Ch Venkata Ramana [3 ]
机构：
[1] Sreenidhi Inst Sci & Technol Autonomous, Hyderabad 501301, Telangana, India
[2] Mahatma Gandhi Inst Technol, Hyderabad 500075, Telangana, India
[3] Jawaharlal Nehru Technol Univ Hyderabad, Dept Chem, Hyderabad 500085, Telangana, India
来源：
VIETNAM JOURNAL OF CHEMISTRY | 2020年 / 58卷 / 06期
关键词：
Benzimidazole; aryl amides; anti‐ bacterial activity; oxidant activity; BENZIMIDAZOLE DERIVATIVES; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT; COMPLEXES;
D O I：
10.1002/vjch.202000079
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Benzimidazole scaffold containing chemical derivatives show superior biological activity. In view of this, we synthesized a combination of benzimidazole and aryl amides. The target compounds (6a-j) were synthesized using ethyl 3-iodobenzoate and benzimidazole as starting materials under microwave conditions. The synthesized compounds were screened against gram (+ve) and gram (-ve) bacteria as well as for their anti-oxidant activity. Compound 6a was proved to be most active in inhibiting the DPPH free radical.
引用
收藏
页码：779 / 784
页数：6
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