Development of Green protocols for the synthesis of 1H-benzo[d]imidazolo aryl amide derivatives and evaluation of their biological activity

被引：0

作者：

Laxminarayana, E. ^{[1
]}

Reddy, B. Srinivasa ^{[2
]}

Reddy, Ch Venkata Ramana ^{[3
]}

机构：

[1] Sreenidhi Inst Sci & Technol Autonomous, Hyderabad 501301, Telangana, India

[2] Mahatma Gandhi Inst Technol, Hyderabad 500075, Telangana, India

[3] Jawaharlal Nehru Technol Univ Hyderabad, Dept Chem, Hyderabad 500085, Telangana, India

来源：

VIETNAM JOURNAL OF CHEMISTRY | 2020年 / 58卷 / 06期

关键词：

Benzimidazole; aryl amides; anti‐ bacterial activity; oxidant activity; BENZIMIDAZOLE DERIVATIVES; ANTIMICROBIAL ACTIVITY; ANTIOXIDANT; COMPLEXES;

D O I：

10.1002/vjch.202000079

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Benzimidazole scaffold containing chemical derivatives show superior biological activity. In view of this, we synthesized a combination of benzimidazole and aryl amides. The target compounds (6a-j) were synthesized using ethyl 3-iodobenzoate and benzimidazole as starting materials under microwave conditions. The synthesized compounds were screened against gram (+ve) and gram (-ve) bacteria as well as for their anti-oxidant activity. Compound 6a was proved to be most active in inhibiting the DPPH free radical.

引用

页码：779 / 784

页数：6

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