Recent Advances on Electrochemical Biosensing Strategies toward Universal Point-of-Care Systems

被引:200
作者
Dai, Yifan [1 ,2 ]
Liu, Chung Chiun [1 ,2 ]
机构
[1] Case Western Reserve Univ, Ctr Elect Design, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Chem & Biomol Engn, Cleveland, OH 44106 USA
关键词
analytical electrochemistry; biosensing; point-of-care; universal biosensors; INDUCED STRAND DISPLACEMENT; SELF-ASSEMBLED MONOLAYERS; EMPLOYS STERIC HINDRANCE; CIRCULATING TUMOR-CELLS; DNA METHYLATION; GOLD NANOPARTICLE; BINDING-PROTEIN; BIOMARKER DETECTION; MASS-SPECTROMETRY; PLASMA-PROTEINS;
D O I
10.1002/anie.201901879
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A number of very recently developed electrochemical biosensing strategies are promoting electrochemical biosensing systems into practical point-of-care applications. The focus of research endeavors has transferred from detection of a specific analyte to the development of general biosensing strategies that can be applied for a single category of analytes, such as nucleic acids, proteins, and cells. In this Minireview, recent cutting-edge research on electrochemical biosensing strategies are described. These developments resolved critical challenges regarding the application of electrochemical biosensors to practical point-of-care systems, such as rapid readout, simple biosensor fabrication method, ultra-high detection sensitivity, direct analysis in a complex biological matrix, and multiplexed target analysis. This Minireview provides general guidelines both for scientists in the biosensing research community and for the biosensor industry on development of point-of-care system, benefiting global healthcare.
引用
收藏
页码:12355 / 12368
页数:14
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