Sister chromatid exchange, (SCE), High-Frequency Cells (HFCs) and SCE distribution patterns in peripheral blood lymphocytes of Spanish adult smokers compared to non-smokers

被引：9

作者：

Sebastia, Natividad ^{[1
]}

Hervas, David ^{[2
]}

Almonacid, Miguel ^{[3
]}

Ignacio Villaescusa, Juan ^{[3
]}

Miguel Soriano, Jose ^{[1
]}

Sahuquillo, Vicenta ^{[3
]}

Esteban, Valentin ^{[4
]}

Barquinero, Joan Francesc ^{[5
]}

Verdu, Gumersindo ^{[6
]}

Cervera, Jose ^{[7
]}

Such, Esperanza ^{[7
]}

Montoro, Alegria ^{[3
]}

机构：

[1] Univ Valencia, Fac Farm, Dept Med Prevent & Salut Publ, E-46100 Burjassot, Spain

[2] Inst Invest Sanitaria La Fe, Unidad Bioestadist IIS La Fe, Valencia, Spain

[3] Hosp Univ Politecn La Fe, Serv Protecc Radiol, Valencia, Spain

[4] Conselleria Sanitat, Direcc Gen Salud Publ, Serv Salud Laboral, Valencia, Spain

[5] SRBE, PRP HOM, IRSN, F-92262 Fontenay Aux Roses, France

[6] Univ Politecn Valencia, Dept Ingn Quim & Nucl, Valencia, Spain

[7] Hosp Univ & Politecn La Fe, Serv Hematol, Valencia, Spain

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2014年 / 66卷

关键词：

Tobacco; Cytogenetic assessment; Biomarker; SCEs; CHROMOSOMAL-ABERRATIONS; GENOTOXICITY; WATERPIPE; SMOKING; TOBACCO; DAMAGE; ASSAY;

D O I：

10.1016/j.fct.2014.01.011

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

According to the International Agency for Research on Cancer, smoking tobacco is a major cause of cancer in humans. It causes about half of all male cancer deaths and an ever increasing number of cancer deaths in females. The aim of this study was to establish whether cigarette smoking increases sister chromatid exchanges (SCEs) in peripheral blood lymphocytes in two Spanish population groups; light and heavy smokers. The mean number of High-Frequency Cells (HFCs) was determined and, the SCE distribution pattern among the chromosomes was analysed represented by a ratio described below. A local sample of 101 adult smokers (n = 48) and non-smokers (n = 53), aged from 18 to 49 years, was studied using SCE levels in peripheral lymphocytes. Heavy smoking (>= 10 cigarettes per day) increased significantly the SCE frequency and the HFC parameters. Neither age nor sex significantly influenced the frequencies in the groups studied. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.

引用

页码：107 / 112

页数：6

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