Sister chromatid exchange, (SCE), High-Frequency Cells (HFCs) and SCE distribution patterns in peripheral blood lymphocytes of Spanish adult smokers compared to non-smokers

被引：9

作者：

Sebastia, Natividad ^{[1
]}

Hervas, David ^{[2
]}

Almonacid, Miguel ^{[3
]}

Ignacio Villaescusa, Juan ^{[3
]}

Miguel Soriano, Jose ^{[1
]}

Sahuquillo, Vicenta ^{[3
]}

Esteban, Valentin ^{[4
]}

Barquinero, Joan Francesc ^{[5
]}

Verdu, Gumersindo ^{[6
]}

Cervera, Jose ^{[7
]}

Such, Esperanza ^{[7
]}

Montoro, Alegria ^{[3
]}

机构：

[1] Univ Valencia, Fac Farm, Dept Med Prevent & Salut Publ, E-46100 Burjassot, Spain

[2] Inst Invest Sanitaria La Fe, Unidad Bioestadist IIS La Fe, Valencia, Spain

[3] Hosp Univ Politecn La Fe, Serv Protecc Radiol, Valencia, Spain

[4] Conselleria Sanitat, Direcc Gen Salud Publ, Serv Salud Laboral, Valencia, Spain

[5] SRBE, PRP HOM, IRSN, F-92262 Fontenay Aux Roses, France

[6] Univ Politecn Valencia, Dept Ingn Quim & Nucl, Valencia, Spain

[7] Hosp Univ & Politecn La Fe, Serv Hematol, Valencia, Spain

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2014年 / 66卷

关键词：

Tobacco; Cytogenetic assessment; Biomarker; SCEs; CHROMOSOMAL-ABERRATIONS; GENOTOXICITY; WATERPIPE; SMOKING; TOBACCO; DAMAGE; ASSAY;

D O I：

10.1016/j.fct.2014.01.011

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

According to the International Agency for Research on Cancer, smoking tobacco is a major cause of cancer in humans. It causes about half of all male cancer deaths and an ever increasing number of cancer deaths in females. The aim of this study was to establish whether cigarette smoking increases sister chromatid exchanges (SCEs) in peripheral blood lymphocytes in two Spanish population groups; light and heavy smokers. The mean number of High-Frequency Cells (HFCs) was determined and, the SCE distribution pattern among the chromosomes was analysed represented by a ratio described below. A local sample of 101 adult smokers (n = 48) and non-smokers (n = 53), aged from 18 to 49 years, was studied using SCE levels in peripheral lymphocytes. Heavy smoking (>= 10 cigarettes per day) increased significantly the SCE frequency and the HFC parameters. Neither age nor sex significantly influenced the frequencies in the groups studied. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.

引用

页码：107 / 112

页数：6

共 29 条

[1] Assessment of DNA damage using chromosomal aberrations assay in lymphocytes of waterpipe smokers
Alsatari, Enas S.
Azab, Mohammad
Khabour, Omar F.
Alzoubi, Karem H.
Sadiq, May F.
[J]. INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH, 2012, 25 (03) : 218 - 224
[2] Nitroimidazole derivatives: non-randomness sister chromatid exchanges in human peripheral blood lymphocytes
Ana Carballo, Marta
Martinez, Romari Alejandra
Dolores Mudry, Marta
[J]. JOURNAL OF APPLIED TOXICOLOGY, 2009, 29 (03) : 248 - 254
[3] CHROMOSOME-ABERRATIONS, MITOGEN-INDUCED BLASTOGENESIS AND PROLIFERATIVE RATE INDEX IN PERIPHERAL LYMPHOCYTES FROM 106 CONTROL INDIVIDUALS OF THE UK POPULATION
ANDERSON, D
JENKINSON, PC
DEWDNEY, RS
FRANCIS, AJ
GODBERT, P
BUTTERWORTH, KR
[J]. MUTATION RESEARCH, 1988, 204 (03): : 407 - 420
[4] [Anonymous], 2012, CHROM 6 COMP
[5] Sister chromatid exchange (SCE) and high-frequency cells (HFC) in peripheral blood lymphocytes of healthy Tunisian smokers
Ben Salah, Ghada
Kamoun, Hassen
Rebai, Ahmed
Ben Youssef, Achraf
Ayadi, Hajer
Beighith-Mahfoudh, Neila
Fourati, Amine
Ayadi, Hamadi
Fakhfakh, Faiza
[J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2011, 719 (1-2) : 1 - 6
[6] SCE ANALYSIS IN HUMAN-LYMPHOCYTES OF A SPANISH CONTROL POPULATION
CARBONELL, E
PERIS, F
XAMENA, N
CREUS, A
MARCOS, R
[J]. MUTATION RESEARCH-ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS, 1995, 335 (01): : 35 - 46
[7] Carrano A.V., 1982, NEW HORIZONS GENETIC, P267
[8] Biomarkers of genotoxicity and genomic instability in a non-human primate, Cebus libidinosus (Cebidae, Platyrrhini), exposed to nitroimidazole derivatives
Dolores Mudry, Marta
Martinez, Romari Alejandra
Nieves, Mariela
Ana Carballo, Marta
[J]. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2011, 721 (01) : 108 - 113
[9] Lack of association between GSTT1 polymorphism and endogenous or benzo[a]pyrene-induced sister chromatid exchanges as analyzed in metaphase or G2-phase lymphocytes
Hatzi, V. I.
Terzoudi, G. I.
Stavropoulou, C.
Malik, S. I.
Makropoulos, V.
Pantelias, G. E.
[J]. MOLECULAR BIOLOGY REPORTS, 2011, 38 (06) : 3959 - 3966
[10] Bleomycin: New perspectives on the mechanism of action
Hecht, SM
[J]. JOURNAL OF NATURAL PRODUCTS, 2000, 63 (01): : 158 - 168

← 1 2 3 →