Stimuli- Responsive Nanocomposite: Potential Injectable Embolization Agent

被引：26

作者：

Chen, Xiuli ^{[1
]}

Huang, Lin ^{[1
]}

Sun, Hao-Jan ^{[2
]}

Cheng, Stephen Z. D. ^{[2
]}

Zhu, Mingqiang ^{[3
]}

Yang, Guang ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Wuhan 430074, Peoples R China

[2] Univ Akron, Dept Polymer Sci, Coll Polymer Sci & Polymer Engn, Akron, OH 44325 USA

[3] Huazhong Univ Sci & Technol, Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2014年 / 35卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ATRP; BC nanowhisker; HCC; PNIPAM; TAE; TRANSFER RADICAL POLYMERIZATION; CELLULOSE NANOCRYSTALS; N-ISOPROPYLACRYLAMIDE; HEPATOCELLULAR-CARCINOMA; NANOCELLULOSE; SURFACES; NANOGEL; FIBERS;

D O I：

10.1002/marc.201300720

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Liver cancer remains a significant medical problem and one promising therapeutic approach is to embolize the tumor. One emerging embolization strategy is to use thermoresponsive materials that can be injected but gel at the tumor site. It is now reported on thermoresponsive nanocomposites generated by grafting poly(N-isopropylacrylamide) chains on bacterial cellulose nanowhiskers. Chemical and physical evidences are provided for grafting and demonstrated a sol-gel transition when the temperature is increased above 34.3 degrees C. Cytotoxicity test in human umbilical vein endothelial cells indicates the excellent biocompatibility of these nanocomposites for use as embolic materials. These results suggest that the nanocomposites offer appropriate properties for embolization of hepatocellular carcinoma.

引用

页码：579 / 584

页数：6

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