Cyclocondensation reaction of heterocyclic carbonyl compounds, Part XIII: Synthesis and cytotoxic activity of some 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines

被引：45

作者：

Gucky, Tomas ^{[1
]}

Frysova, Iveta ^{[1
]}

Slouka, Jan ^{[1
]}

Hajduch, Marian ^{[2
,3
,4
]}

Dzubak, Petr ^{[2
,3
,4
]}

机构：

[1] Palacky Univ, Dept Organ Chem, Fac Sci, Olomouc 77146, Czech Republic

[2] Palacky Univ, Expt Med Lab, Dept Pediat, Fac Med, CR-77147 Olomouc, Czech Republic

[3] Palacky Univ, Expt Med Lab, Dept Oncol, Fac Med, CR-77147 Olomouc, Czech Republic

[4] Fac Hosp, Olomouc, Czech Republic

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 02期

关键词：

Pyrazolo[4,3-e][1,2,4]triazines; Cytotoxic activity; PSEUDOMONAS-FLUORESCENS; BIOLOGICAL EVALUATION; CC-1065; ANALOGS; COMBRETASTATIN; CYCLIZATION; SERIES; AGENTS;

D O I：

10.1016/j.ejmech.2008.05.026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of the 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines (17a-20f) have been synthesized in five steps. The cytotoxic activity of all of the newly synthesized compounds has been tested in vitro against five cancer cell lines. Several compounds demonstrated significant broad cytotoxic activity in low micromolar range, while others were selectively active against lung adenocarcinoma cell line A549. (c) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：891 / 900

页数：10

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