Synthesis, Antimicrobial and Antioxidant Activities of Some Benzimidazole Derivatives

被引：10

作者：

Kus, Canan ^{[1
]}

Ayhan-Kilcigil, Guelguen ^{[1
]}

Tuncbilek, Meral ^{[1
]}

Altanlar, Nurten ^{[2
]}

Coban, Tuelay ^{[3
]}

Can-Eke, Benay ^{[3
]}

Iscan, Muemtaz ^{[3
]}

机构：

[1] Ankara Univ, Dept Pharmaceut Chem, Fac Pharm, TR-06100 Ankara, Turkey

[2] Ankara Univ, Dept Pharmaceut Microbiol, Fac Pharm, TR-06100 Ankara, Turkey

[3] Ankara Univ, Dept Toxicol, Fac Pharm, TR-06100 Ankara, Turkey

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2009年 / 6卷 / 05期

关键词：

Benzimidazole; Synthesis; Antimicrobial; Antioxidant; LIPID-PEROXIDATION; INDOLE;

D O I：

10.2174/1570180810906050374

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of benzimidazole compounds namely, N-(4-(1H-benzimidazol-2-yl) phenyl)-4-(1H-benzimidazol-2yl)-benzamide derivatives (8-10) and N-(3- or 4-(1H-benzimidazol-2-yl) phenyl)-2-phenyl-1H-benzimidazole-5-carboxamide derivatives (18-21) were synthesized and antibacterial and antioxidant activities were evaluated. Antibacterial activities of 9, 10, 18, and 20 against MRSA-isolate are equal to ampicillin. Compounds 18, 19, and 21 displayed better antifungal activities against Candida albicans. Antioxidant properties were evaluated by several methods, such as inhibition of lipid peroxidation, superoxide anion production, and DPPH stable free radical, and also their effects on hepatic cytochrome P450 (CYP) dependent ethoxyresorufin O-deethylase (EROD) enzyme were determined in rats in vitro. Compounds 18 and 20 had strong scavenger effect on superoxide anion (90%, and 99%, respectively) at 10(-3) M concentration. Compound 19 showed significant inhibition on EROD activity with 98%, which is better than that of caffeine being a specific inhibitor of EROD activity (85%).

引用

页码：374 / 379

页数：6

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