Advances in the diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis

被引:28
作者
Luna, Laura E. Moreno [1 ]
Gores, Gregory J. [1 ]
机构
[1] Mayo Clin Coll Med, Miles & Shirley Fiterman Ctr Digest Dis, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA
关键词
D O I
10.1002/lt.20938
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
In patients with PSC, CCA is the most dreaded complication. The survival of patients with PSC plus CCA is greatly diminished. Neither a specific serum tumor marker nor any imaging studies have been proved to be 100% accurate in the detection of CCA. However, more recently developed techniques such as DIA and FISH have shown to improve on the results in patients with negative routine cytology. On the basis of these data, we now routinely use these studies for the diagnosis of CCA in PSC (Table 1). Patients should be followed yearly with MRI studies. If there is a rapid change in a focal stricture and/or the rapid onset of jaundice, we advise direct cholangiography (usually by endoscopic retrograde pancreatography), and brushings and biopsies of the dominant stricture. Where available, advanced cytologic studies for aneuploidy should be performed.
引用
收藏
页码:S15 / S19
页数:5
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