Synthesis of β-Amino Alcohols via the Reduction of Lactamides Derived from Ethyl (2S)-Lactate with Borane-Methyl Sulfide

被引：10

作者：

Lewis, Frank W. ^{[1
]}

Eichler, Matthias C. ^{[1
]}

Grayson, David H. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Univ Chem Lab, Ctr Synth & Chem Biol, Dublin 2, Ireland

来源：

SYNLETT | 2009年 / 12期

关键词：

lactamides; borane-methyl sulfide; amino alcohols; asymmetric synthesis; reductions; ACTIVE ANTIFUNGAL AZOLES; 1,2-AMINO ALCOHOLS; ASYMMETRIC-SYNTHESIS; ORGANOZINC REAGENTS; CHIRAL AUXILIARIES; KINETIC RESOLUTION; ORGANIC-COMPOUNDS; ACIDS; DERIVATIVES; HYDROGENATION;

D O I：

10.1055/s-0029-1217538

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reactions of ethyl (2S)-lactate with various amines affords lactamides that are reduced with borane-methyl Sulfide in the presence of boron trifluoride etherate to generate enantiomerically pure P-amino alcohols in good yield.

引用

页码：1923 / 1928

页数：6

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