Age at Menarche and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study Among 27,482 Women

被引：26

作者：

Chen, Liwei ^{[1
]}

Li, Shanshan ^{[2
]}

He, Chunyan ^{[3
,4
]}

Zhu, Yeyi ^{[2
]}

Louis, Germaine M. Buck ^{[2
]}

Yeung, Edwina ^{[2
]}

Hu, Frank B. ^{[5
,6
,7
,8
]}

Zhang, Cuilin ^{[2
]}

机构：

[1] Clemson Univ, Dept Publ Hlth Sci, Clemson, SC USA

[2] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Div Epidemiol Stat & Prevent Res, NIH, Bethesda, MD USA

[3] Indiana Univ Sch Med, Dept Publ Hlth & Melvin, Indianapolis, IN 46202 USA

[4] Indiana Univ Sch Med, Bren Simon Canc Ctr, Indianapolis, IN 46202 USA

[5] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[6] Brigham & Womens Hosp, Dept Med, Channing Lab, 75 Francis St, Boston, MA 02115 USA

[7] Harvard Univ, Sch Med, Boston, MA USA

[8] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

来源：

DIABETES CARE | 2016年 / 39卷 / 03期

基金：

美国国家卫生研究院;

关键词：

ASSOCIATION; ADULTS;

D O I：

10.2337/dc15-2011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVETo examine the association between age at menarche and risk of gestational diabetes mellitus (GDM).RESEARCH DESIGN AND METHODSA prospective cohort study of 42,109 eligible pregnancies from 27,482 women in the Nurses' Health Study II.RESULTSThe adjusted risk ratios for GDM across the age at menarche categories (11, 12, 13, and 14 years) were 1.34 (95% CI 1.14-1.58), 1.13 (0.97-1.31), 1.11 (0.95-1.29), and 1.00 (referent; P for trend = 0.0005), respectively. Analysis of the mediating effect indicated that 42.1% (P = 0.0007) of the association was mediated through prepregnancy BMI.CONCLUSIONSThese findings suggested that earlier menarche was significantly associated with an increased risk of GDM. This association was largely mediated through prepregnancy excessive body adiposity.

引用

页码：469 / 471

页数：3

共 15 条

[1]

[Anonymous], 2004, Diabetes Care, V27, pS88, DOI [10.2337/diacare.27.2007.S88, DOI 10.2337/DIACARE.27.2007.S88]

[2] SOME ENDOCRINE CHARACTERISTICS OF EARLY MENARCHE, A RISK FACTOR FOR BREAST-CANCER, ARE PRESERVED INTO ADULTHOOD [J].

APTER, D ;

REINILA, M ;

VIHKO, R .

INTERNATIONAL JOURNAL OF CANCER, 1989, 44 (05) :783-787

[3] Sex hormone-binding globulin in gestational diabetes [J].

Bartha, JL ;

Comino-Delgado, R ;

Romero-Carmona, R ;

Gomez-Jaen, MD .

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2000, 79 (10) :839-845

[4] Age at Menarche and Type 2 Diabetes Risk The EPIC-InterAct study [J].

Elks, Cathy E. ;

Ong, Ken K. ;

Scott, Robert A. ;

van der Schouw, Yvonne T. ;

Brand, Judith S. ;

Wark, Petra A. ;

Amiano, Pilar ;

Balkau, Beverley ;

Barricarte, Aurelio ;

Boeing, Heiner ;

Fonseca-Nunes, Ana ;

Franks, Paul W. ;

Grioni, Sara ;

Halkjaer, Jytte ;

Kaaks, Rudolf ;

Key, Timothy J. ;

Khaw, Kay Tee ;

Mattiello, Amalia ;

Nilsson, Peter M. ;

Overvad, Kim ;

Palli, Domenico ;

Quiros, J. Ramon ;

Rinaldi, Sabina ;

Rolandsson, Olov ;

Romieu, Isabelle ;

Sacerdote, Carlotta ;

Sanchez, Maria-Jose ;

Spijkerman, Annemieke M. W. ;

Tjonneland, Anne ;

Tormo, Maria-Jose ;

Tumino, Rosario ;

Daphne, L. Van der A. ;

Forouhi, Nita G. ;

Sharp, Stephen J. ;

Langenberg, Claudia ;

Riboli, Elio ;

Wareham, Nicholas J. .

DIABETES CARE, 2013, 36 (11) :3526-3534

[5] Effects of age at menarche, reproductive years, and menopause on metabolic risk factors for cardiovascular diseases [J].

Feng, Yan ;

Hong, Xiumei ;

Wilker, Elissa ;

Li, Zhiping ;

Zhang, Wenbin ;

Jin, Delai ;

Liu, Xue ;

Zang, Tonghua ;

Xu, Xiping ;

Xu, Xin .

ATHEROSCLEROSIS, 2008, 196 (02) :590-597

[6] The relation of menarcheal age to obesity in childhood and adulthood: The Bogalusa heart study [J].

David S Freedman ;

Laura Kettel Khan ;

Mary K Serdula ;

William H Dietz ;

Sathanur R Srinivasan ;

Gerald S Berenson .

BMC Pediatrics, 3 (1)

[7] Age at Menarche and Risk of Type 2 Diabetes: Results From 2 Large Prospective Cohort Studies [J].

He, Chunyan ;

Zhang, Cuilin ;

Hunter, David J. ;

Hankinson, Susan E. ;

Louis, Germaine M. Buck ;

Hediger, Mary L. ;

Hu, Frank B. .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2010, 171 (03) :334-344

[8] Association of age at menarche with cardiovascular risk factors, vascular structure, and function in adulthood:: the Cardiovascular Risk in Young Finns study [J].

Kivimaki, Mika ;

Lawlor, Debbie A. ;

Smith, George Davey ;

Elovainio, Marko ;

Jokela, Markus ;

Keltikangas-Jarvinen, Liisa ;

Vahtera, Jussi ;

Taittonen, Leena ;

Juonala, Markus ;

Viikari, Jorma Sa ;

Raitakari, Olli T. .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2008, 87 (06) :1876-1882

[9]

Laitinen J, 2001, AM J CLIN NUTR, V74, P287

[10] Association between age at menarche and risk of diabetes in adults: results from the EPIC-Norfolk cohort study [J].

Lakshman, R. ;

Forouhi, N. ;

Luben, R. ;

Bingham, S. ;

Khaw, K. ;

Wareham, N. ;

Ong, K. K. .

DIABETOLOGIA, 2008, 51 (05) :781-786

← 1 2 →