Isatin Derivatives with Potential Antitubercular Activities

被引：61

作者：

Jiang, Dan ^{[1
]}

Wang, Gang-Qiang ^{[1
]}

Liu, Xiaofeng ^{[2
,3
]}

Zhang, Zhenbin ^{[2
]}

Feng, Lian-Shun ^{[4
]}

Liu, Ming-Liang ^{[5
,6
]}

机构：

[1] Hubei Univ Sci & Technol, Sch Nucl Technol & Chem & Biol, Xianning, Peoples R China

[2] Zhejiang Xianju Junye Pharmaceut Co Ltd, Xianju 317300, Zhejiang, Peoples R China

[3] Wuhan Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430081, Hubei, Peoples R China

[4] WuXi AppTec Wuhan, Wuhan, Hubei, Peoples R China

[5] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China

[6] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2018年 / 55卷 / 06期

关键词：

IN-VITRO ANTIMYCOBACTERIAL; REVERSE-TRANSCRIPTASE INHIBITORS; BIOLOGICAL EVALUATION; HYBRIDS DESIGN; SCHIFF-BASES; ANTIBACTERIAL ACTIVITIES; MOLECULAR HYBRIDIZATION; ANTITUMOR-ACTIVITY; QUINOLINE HYBRIDS; MANNICH-BASES;

D O I：

10.1002/jhet.3189

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tuberculosis is a life-threatening chronic infectious disease, which primarily affects the lungs but can spread to other vital organs. The re-emergence and wide spread of new virulent forms of Mycobacterium tuberculosis that are resistant to some or all first and second line antitubercular agents has reached an alarming level in recent decades. Thus, it is imperative to develop more effective agents. Isatin derivatives are endowed with diverse biological properties, therefore thousands of isatin derivatives have been synthesized in hopes of discovering new candidates with potential antitubercular activities against both drug-susceptible and drug-resistant strains. This review summarizes the recent developments of isatin derivatives with potential antitubercular activities.

引用

页码：1263 / 1279

页数：17

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