Synthesis and single-crystal characterization of novel 2-ferrocenyl-4H-pyrazolo[5,1-c][1,4]oxazin-4-one derivatives

被引：12

作者：

Xie, Yong-Sheng ^{[1
]}

Zhao, Bao-Xiang ^{[1
]}

Lv, Hong-Shui ^{[1
]}

Li, Ji-Kun ^{[2
]}

Wang, Bai-Shan ^{[1
]}

Shin, Dong-Soo ^{[3
]}

机构：

[1] Shandong Univ, Inst Organ Chem, Sch Chem & Chem Engn, Jinan 250100, Peoples R China

[2] Taishan Univ, Dept Mat Sci & Chem Engn, Tai An 271021, Shandong, Peoples R China

[3] Changwon Natl Univ, Dept Chem, Chang Won 641773, South Korea

来源：

JOURNAL OF MOLECULAR STRUCTURE | 2009年 / 930卷 / 1-3期

关键词：

Ferrocene; Pyrazole-fused oxazinone; Synthesis; X-ray structure; COAGULATION-FACTOR XA; ESTROGEN-RECEPTOR MODULATORS; PRELIMINARY BIOLOGICAL EVALUATION; ORALLY BIOAVAILABLE INHIBITOR; PYRAZIN-4(5H)-ONE DERIVATIVES; FERROCENYL PYRAZOLES; BREAST-CANCER; HIGHLY POTENT; AGENTS; SERMS;

D O I：

10.1016/j.molstruc.2009.04.042

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A series of novel 2-ferrocenyl-6-substituted-4H-pyrazolo[5,1-c][1,4]oxazin-4-one derivatives were synthesized by the intra-esterification reaction of ethyl 1-(2-aryl-2-oxoethyl)-3-ferrocenyl-1H-pyrazole-5-carboxylate in the presence of magnesium bromide and diisopropylethylamine in one-pot procedure. The structures of compounds were characterized by H-1 NMR, C-13 NMR, IR, HRMS and X-ray diffraction analysis. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：83 / 87

页数：5

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