Mangiferin regulates cognitive deficits and heme oxygenase-1 induced by lipopolysaccharide in mice

被引：17
作者：
Fu, Yanyan [1 ,2 ]
Liu, Hongzhi [1 ]
Song, Chengjie [3 ]
Zhang, Fang [1 ]
Liu, Yi [2 ]
Wu, Jian [2 ]
Wen, Xiangru [1 ,3 ]
Liang, Chen [4 ]
Ma, Kai [5 ]
Li, Lei [6 ]
Zhang, Xunbao [7 ]
Shao, Xiaoping [7 ]
Sun, Yafeng [1 ]
Du, Yang [1 ]
Song, Yuanjian [1 ,8 ,9 ]
机构：
[1] Xuzhou Med Coll, Jiangsu Key Lab Brain Dis Bioinformat, Xuzhou 221004, Jiangsu, Peoples R China
[2] Xuzhou Med Coll, Dept Cell Biol & Neurobiol, Xuzhou 221004, Jiangsu, Peoples R China
[3] Xuzhou Med Coll, Dept Physiol, Xuzhou 221004, Jiangsu, Peoples R China
[4] Xuzhou Med Coll, Affiliated Hosp, Dept Endocrinol, Xuzhou 221002, Jiangsu, Peoples R China
[5] Xuzhou Med Coll, Dept Med Informat, Xuzhou 221004, Jiangsu, Peoples R China
[6] Xuzhou Med Coll, Affiliated Hosp, Dept Geriatr, Xuzhou 221002, Jiangsu, Peoples R China
[7] Xuzhou Med Coll, Sch Publ Hlth, Xuzhou 221004, Jiangsu, Peoples R China
[8] Xuzhou Med Coll, Dept Genet, Xuzhou 221004, Jiangsu, Peoples R China
[9] Xuzhou Med Coll, Neurobiol Res Ctr, Xuzhou 221004, Jiangsu, Peoples R China
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2015年 / 29卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Mangiferin; Lipopolysaccharide; Cognitive; Heme oxygenase-1; NF-KAPPA-B; MICROGLIAL CELLS; INFLAMMATORY MEDIATORS; SIGNALING PATHWAYS; COX-2; EXPRESSION; MAPK PATHWAYS; BV2; MICROGLIA; ACTIVATION; LPS; RATS;
D O I：
10.1016/j.intimp.2015.10.035
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Accumulating evidence reveals that lipopolysaccharide (ITS) can induce neuroinflammation, ultimately leading to cognitive deficits. Mangiferin, a natural glucoxilxanthone, is known to possess various biological activities. The present study aimed to investigate the effects of mangiferin on LPS-induced cognitive deficits and explore the underlying mechanisms. Brain injury was induced in mice via intraperitoneal LPS injection (1 mg/kg) for five consecutive days. Mangiferin was orally pretreatmented (50 mg/kg) for seven days and then treatmented (50 mg/kg) for five days after LPS injection. The Morris water maze was used to detect changes in cognitive function. Immunohistochemical and immunoblotting were respectively performed to measure the expression of interleukin-6 (IL-6) and heme oxygenase-1 (HO-1) in the hippocampus. The results showed that mangiferin can ameliorate cognitive deficits. Moreover, mangiferin decreased LPS-induced IL-6 production and increase HO-1 in the hippocampus. Taken together, these results suggest that mangiferin attenuates LPS-induced cognitive deficits, which may be potentially linked to modulating HO-1 in the hippocampus. (C) 2015 Published by Elsevier B.V.
引用
收藏
页码：950 / 956
页数：7
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