Dissociative Bioorthogonal Reactions

被引：68

作者：

Tu, Julian ^{[1
]}

Xu, Minghao ^{[1
]}

Franzini, Raphael M. ^{[1
]}

机构：

[1] Univ Utah, Dept Med Chem, 30 S 2000 E, Salt Lake City, UT 84112 USA

来源：

CHEMBIOCHEM | 2019年 / 20卷 / 13期

关键词：

bioorthogonal chemistry; cleavage reactions; cycloaddition; drug delivery; protecting groups; OLIGONUCLEOTIDE-TEMPLATED REACTIONS; TRIGGERED FLUORESCENCE PROBE; CATALYZED BETA-ELIMINATION; DRUG-RELEASE; TRANS-CYCLOOCTENE; CLICK CHEMISTRY; CELL-SURFACE; ALLYLCARBAMATE CLEAVAGE; CHEMICAL ACTIVATION; COMPLEX CATALYSIS;

D O I：

10.1002/cbic.201800810

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioorthogonal reactions that proceed readily under physiological conditions without interference from biomolecules have found widespread application in the life sciences. Complementary to the bioorthogonal reactions that ligate two molecules, reactions that release a molecule or cleave a linker are increasingly attracting interest. Such dissociative bioorthogonal reactions have a broad spectrum of uses, for example, in controlling bio-macromolecule activity, in drug delivery, and in diagnostic assays. This review article summarizes the developed bioorthogonal reactions linked to a release step, outlines representative areas of the applications of such reactions, and discusses aspects that require further improvement.

引用

页码：1615 / 1627

页数：13

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