Tripartite Motif 16 Inhibits the Migration and Invasion in Ovarian Cancer Cells

被引：29
作者：
Tan, Hongwei [1 ]
Qi, Jin [1 ]
Chu, Guanghua [1 ]
Liu, Zhaoyang [1 ]
机构：
[1] Northwest Women & Childrens Hosp, Dept Gynecol, 1616 Yanxiang Rd, Xian 710061, Shaanxi, Peoples R China
来源：
ONCOLOGY RESEARCH | 2017年 / 25卷 / 04期
关键词：
Tripartite motif 16 (TRIM16); Ovarian cancer; Cell invasion; Epithelial-mesenchymal transition (EMT); HEDGEHOG SIGNALING PATHWAY; SONIC HEDGEHOG; TRIM PROTEINS; PROLIFERATION; PERSPECTIVES; METASTASIS; ACTIVATION; TRANSITION;
D O I：
10.3727/096504016X14758370595285
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tripartite motif 16 (TRIM16), a member of the RING B-box coiled-coil (RBCC)/tripartite motif (TRIM) protein family, has been shown to play a role in tumor development and progression. However, the role of TRIM16 in ovarian cancer has never been revealed. Thus, in this study, we investigated the roles and mechanisms of TRIM16 in ovarian cancer. Our results demonstrated that TRIM16 expression was low in ovarian cancer cell lines. In addition, overexpression of TRIM16 significantly inhibited the migration and invasion in vitro, as well as suppressed the epithelial-mesenchymal transition (EMT) phenotype in ovarian cancer cells. Furthermore, overexpression of TRIM16 greatly inhibited the protein expression levels of Shh, Smo, Ptc, Gli-1, MMP2, and MMP9 in ovarian cancer cells. Taken together, these results strongly suggest that TRIM16 inhibits the migration and invasion via suppressing the Sonic hedgehog signaling pathway in ovarian cancer cells. Thus, TRIM16 may be a novel potential therapeutic target for ovarian cancer.
引用
收藏
页码：551 / 558
页数：8
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