Efficacy and safety of repetitive transcranial magnetic stimulation for peripartum depression: A meta-analysis of randomized controlled trials

被引：9
作者：
Liu, Chaomeng [1 ,2 ]
Pan, Weigang [1 ,2 ]
Jia, Lina [1 ,2 ]
Li, Li [1 ,2 ]
Zhang, Xinyu [1 ,2 ]
Ren, Yanping [1 ,2 ,3 ]
Ma, Xin [1 ,2 ,3 ]
机构：
[1] Capital Med Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
[2] Capital Med Univ, Beijing Key Lab Mental Disorders, Beijing Anding Hosp, Beijing, Peoples R China
[3] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China
来源：
PSYCHIATRY RESEARCH | 2020年 / 294卷
关键词：
Repetitive transcranial magnetic stimulation; Peripartum depression; Meta-analysis; Safety; Randomized controlled trial; POSTPARTUM DEPRESSION; ELECTROCONVULSIVE-THERAPY; ANTIDEPRESSANT USE; MENTAL-DISORDERS; MAJOR DEPRESSION; PREGNANCY; RISK; TMS;
D O I：
10.1016/j.psychres.2020.113543
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
This study aims to summarize and systematically review the efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) for women with peripartum depression (PPD). Several databases (Wanfang, CNKI, VIP, CBM, PubMed, Embase, Cochrane Library, PsyINFO, Web of Science, and Clinical trial) were searched from inception until April 12, 2020. In total, ten randomized controlled trials (RCTs) met the eligibility criteria and were included in this systematic review. We calculated the combined effect size (standardized mean difference [SMD] and odds ratio [OR]) for the corresponding effects models. The aggregated result of 10 trials indicated a significant benefit of rTMS on PPD, and the aggregated result of remission showed significantly positive effects of Test group VS. Control group. In terms of treatment adverse effects, the aggregated result showed no statistical significance of headache and dry mouth between the two groups. The results of the meta-analysis suggest that rTMS is an effective and safe intervention for PPD. Owing to poor methodological quality among the included studies, high-quality multicenter RCTs are needed to further verify the effects of this treatment.
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页数：10
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