Ethyl (S)-2-Benzamido-5-[(4,6-dimethylpyrimidin-2-yl)amino]pentanoate

被引：0
作者：
Leyva-Acuna, Mario A. [1 ]
Delgado-Vargas, Francisco [2 ]
Lopez-Angulo, Gabriela [1 ]
Montes-Avila, Julio [1 ,2 ]
机构：
[1] Univ Autonoma Sinaloa, Fac Ciencias Quim Biol, Programa Reg Posgrad Biotecnol, Ciudad Univ, Culiacan 80010, Sin, Mexico
[2] Univ Autonoma Sinaloa, Fac Ciencias Quim Biol, Programa Posgrad Ciencias Biomed, Ciudad Univ, Culiacan 80010, Sin, Mexico
来源：
MOLBANK | 2020年 / 2020卷 / 04期
关键词：
pyrimidines; l-arginine; microwave irradiation; L-ARGININE; DESIGN; PYRIMIDINES; HYBRIDS;
D O I：
10.3390/M1166
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pyrimidines are compounds with a wide range of biological activities, and the synthesis of pyrimidine derivatives-useful in chemical and medicinal applications-is important in medicinal chemistry. This work shows the synthesis under microwave irradiation of the novel compound ethyl (S)-2-benzamido-5-[(4,6-dimethylpyrimidin-2-yl)amino]pentanoate (3) from (S)-N-alpha-benzoyl-l-arginine ethyl ester hydrochloride (1) and acetylacetone (2). Compound 3 was easily purified, obtained in moderate yield (70%), and fully characterized by UV-Vis, FTIR-ATR spectroscopy, H-1-NMR, C-13-NMR, HRMS, and EI-MS.
引用
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页码：1 / 5
页数：5
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