Gentamicin sulphate release from bioactive ceramic calcium silicates

被引：2

作者：

Cortes-Hernandez, D. A. ^{[1
]}

Bretado-Aragon, L. A. ^{[1
]}

Ortega-Lara, W. ^{[1
]}

Renteria-Zamarron, D. ^{[1
]}

Salinas-Delgado, Y. ^{[2
]}

机构：

[1] Cinvestav Unidad Saltillo, Carr Saltillo Mty Km 13,Apdo Postal 663, Saltillo 25000, Coahuila, Mexico

[2] Unidad Invest Biomed IMSS, Durango, CO 34067 USA

来源：

BIOCERAMICS 21 | 2009年 / 396-398卷

关键词：

Wollastonite; Akermanite; Bioactivity; Drug delivery system; Gentamicin sulphate; IN-VITRO;

D O I：

10.4028/www.scientific.net/KEM.396-398.527

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Gentamicin sulphate was mixed with two different sol-gel derived calcium silicates (akermanite or wollastonite). Each of the Mixtures was isostatically pressed. Samples were immersed in simulated body fluid for 21 days. The presence of the antibiotic showed no effect on the in vitro bioactivity of the ceramics. For evaluating the gentamicin sulphate release, samples were immersed in a phosphate buffered saline solution for different periods of time. Most of the gentamicin sulphate was released during the first 7 days. However, akermanite showed a lower antibiotic release rate than that observed for wollastonite.

引用

页码：527 / 530

页数：4

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