The contribution of maternal race/ethnicity and fetal sex to prematurity in twins

被引：8

作者：

Dailey, Tanya L. ^{[1
]}

Jayakrishnan, Asha

Phipps, Maureen ^{[2
,3
]}

Raker, Christina A. ^{[2
]}

Chien, Edward K. ^{[1
]}

机构：

[1] Brown Univ, Women & Infants Hosp Rhode Isl, Warren Alpert Med Sch, Div Maternal Fetal Med, Providence, RI 02912 USA

[2] Brown Univ, Women & Infants Hosp Rhode Isl, Warren Alpert Med Sch, Div Res, Providence, RI 02912 USA

[3] Brown Univ, Women & Infants Hosp Rhode Isl, Warren Alpert Med Sch, Dept Obstet & Gynecol,Dept Community Hlth, Providence, RI 02912 USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2009年 / 201卷 / 01期

关键词：

gender; preterm birth; race; sex; twins; PRETERM BIRTH; DEHYDROEPIANDROSTERONE-SULFATE; TESTOSTERONE; GESTATION; DELIVERY; LABOR; RISK; RACE;

D O I：

10.1016/j.ajog.2009.03.005

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: The contribution of male fetal sex to twin preterm birth (PTB) rates was evaluated in the United States. STUDY DESIGN: The 2002 National Center for Health Statistics Natality database was analyzed for fetal sex and twin gestations based on birth sex for MM and FF pairs (M, male; F, female). Multivariable Cox proportional hazards regression was applied to estimate the hazard ratio for PTB with adjustments for known risks. RESULTS: Thirty-three thousand nine hundred twenty-six pairs were analyzed. PTBs between 20-36 completed weeks occurred in 59.1% MM pairs and 57.5% FF pairs. MM sex was an independent risk factor for PTB. This effect was greatest for deliveries between 20-29 weeks (hazard ratio, 1.224; 95% CI, 1.113-1.346). The effect was most pronounced in non-Hispanic white MM pairs. CONCLUSION: In the United States, MM pairs are at greater risk for PTB. Race and ethnicity modulate sex effects. Further studies are needed to understand potential mechanisms.

引用

页码：68.e1 / 68.e6

页数：6

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