Pharmacological investigation on the wound healing effects of Radix Rehmanniae in an animal model of diabetic foot ulcer

被引:90
作者
Lau, T. W. [1 ]
Lam, F. F. Y. [2 ]
Lau, K. M. [1 ]
Chan, Y. W. [1 ]
Lee, K. M. [1 ]
Sahota, D. S. [3 ]
Ho, Y. Y. [4 ]
Fung, K. P. [1 ,4 ]
Leung, P. C. [1 ]
Lau, C. B. S. [1 ]
机构
[1] Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Dept Pharmacol, Shatin, Hong Kong, Peoples R China
[3] Chinese Univ Hong Kong, Dept Obstet & Gynaecol, Shatin, Hong Kong, Peoples R China
[4] Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China
关键词
Radix Rehmanniae; Rehmannia glutinosa; Diabetic foot ulcer; Chinese medicine; Wound healing; ENDOTHELIAL GROWTH-FACTOR; INCREASED INSULIN ACTION; BLOOD-FLOW RESPONSE; VASCULAR-PERMEABILITY; NEONATAL STREPTOZOTOCIN; INDUCED EDEMA; STEM BARK; ANGIOGENESIS; RAT; EXPRESSION;
D O I
10.1016/j.jep.2009.02.010
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Ethnopharmacological relevance: Radix Rehmanniae (RR) has a very long history of usage in traditional Chinese medicine and is usually one of the principal herb found in many herbal formulae used in diabetic foot ulcer. Aim of the study: RR aqueous extract was investigated for its wound healing effects in a diabetic foot ulcer rat model and its detailed mechanism of actions. Materials and methods: A previously established diabetic foot ulcer rat model was used to assess the effect of RR extract on wound area reduction, tissue regeneration and angiogenesis. Carrageenan-induced inflammation rat model was used for inflammation study; and diabetic control was evaluated using a neonatal streptozotocin-induced diabetic rat model. Results: In the RR treated group, a trend of reduction of the wound area was observed from days 8 to 18 and a significant difference (as compared with control group) was found on day 8. The ulcer healing effect of RR extract was further supported by better developed scars and epithelialization as well as good formation of capillaries with enhanced VEGF expression. Carrageenan-induced inflammation was also significantly alleviated with RR extract. Conclusions: Our results demonstrated for the first time that Radix Rehmanniae was effective in promoting diabetic foot ulcer healing in rats through the processes of tissue regeneration, angiogenesis and inflammation control, but not glycemia control. The present study provided scientific basis to support the traditional use of Radix Rehmanniae in diabetic foot ulcer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:155 / 162
页数:8
相关论文
共 50 条
[41]   Wound healing effect of Vimlapanakarma with Jatyadi tailam in diabetic foot [J].
Kulkarni, Yogesh Sheshagirirao ;
Emmi, Shashidhar V. ;
Dongargaon, Tajahmed N. ;
Wali, Amruta A. .
ANCIENT SCIENCE OF LIFE, 2015, 34 (03) :171-174
[42]   The in vivo and in vitro diabetic wound healing effects of a 2-herb formula and its mechanisms of action [J].
Tam, Jacqueline Chor Wing ;
Lau, Kit Man ;
Liu, Cheuk Lun ;
To, Ming Ho ;
Kwok, Hin Fai ;
Lai, Kwok Kin ;
Lau, Ching Po ;
Ko, Chun Hay ;
Leung, Ping Chung ;
Fung, Kwok Pui ;
Lau, Clara Bik San .
JOURNAL OF ETHNOPHARMACOLOGY, 2011, 134 (03) :831-838
[43]   MicroRNA miR-145-5p Inhibits Cutaneous Wound Healing by Targeting PDGFD in Diabetic Foot Ulcer [J].
Wang, Chun ;
Huang, Li ;
Li, Juan ;
Liu, Dan ;
Wu, Biaoliang .
BIOCHEMICAL GENETICS, 2024, 62 (04) :2437-2454
[44]   Wound bed preparation for ischemic diabetic foot ulcer [J].
Zhang, Zhaoxin ;
Lv, Lei ;
Guan, Sheng .
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (01) :897-903
[45]   Chinese medicine ulcer oil promotes the healing of diabetic foot ulcers [J].
Jia, Hui ;
Yang, Bohua ;
Li, Youshan ;
Liang, Chen ;
Lu, Haibin ;
Lin, Dongyang ;
Ju, Shang .
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2018, 46 (07) :2679-2686
[46]   Vildagliptin promotes diabetic foot ulcer healing through autophagy modulation [J].
Biros, Erik ;
Vangaveti, Venkat ;
Malabu, Usman .
DIABETOLOGY & METABOLIC SYNDROME, 2024, 16 (01)
[47]   L-Glutamine Accelerates Wound Healing in Diabetic Foot Ulcers in Experimental Rats [J].
Pei, Shaokun ;
Li, Minjie ;
Li, Qiang ;
Li, Huixiao ;
Pang, Zhonghui .
INTERNATIONAL JOURNAL OF PHARMACOLOGY, 2022, 18 (01) :153-163
[48]   Wound healing effects of dipeptidyl peptidase-4 inhibitors: An emerging concept in management of diabetic foot ulcer-A review [J].
Saboo, Apoorva ;
Rathnayake, Ayeshmanthe ;
Vangaveti, Venkat N. ;
Malabu, Usman H. .
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS, 2016, 10 (02) :113-119
[49]   Rationale of Orthosiphon aristatus for Healing Diabetic Foot Ulcer [J].
Abdullah, Farah Izana ;
Chua, Lee Suan ;
Bohari, Siti Pauliena Mohd ;
Sari, Eka .
NATURAL PRODUCT COMMUNICATIONS, 2020, 15 (09)
[50]   Effect of Infrared Radiation on the Healing of Diabetic Foot Ulcer [J].
Hakim, Ashrafalsadat ;
Moghadam, Ali Sadeghi ;
Shariati, Abdalali ;
Karimi, Hamid ;
Haghighizadeh, Mohamad Hossien .
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 2016, 14 (03)