Panton-Valentine Leukocidin-positive Staphylococcus aureus: a potentially significant pathogen in cystic fibrosis

被引：3
|
作者：
Barry, Peter J. [1 ]
Isalska, Barbara J. [2 ]
Jones, Andrew M. [3 ]
机构：
[1] Univ S Manchester Hosp, Manchester Adult Cyst Fibrosis Ctr, Manchester M23 9LT, Lancs, England
[2] Univ S Manchester Hosp, Dept Microbiol, Manchester M23 9LT, Lancs, England
[3] Univ Manchester, Inst Inflammat & Repair, Manchester M13 9PL, Lancs, England
来源：
PAEDIATRIC RESPIRATORY REVIEWS | 2014年 / 15卷
关键词：
PVL; Cystic fibrosis; Staphylococcus aureus; Pneumonia; Infection control; NECROTIZING PNEUMONIA; TRANSMISSION; PREVALENCE;
D O I：
10.1016/j.prrv.2014.04.008
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Staphylococcus aureus is an important pathogen within the context of cystic fibrosis lung disease. Case reports have identified a strong association between the toxin Panton-Valentine Leukocidin (PVL) and lethal necrotizing pneumonia in healthy immunocompetent patients. PVL+ strains of Staphylococcus aureus have also been identified in patients with cystic fibrosis. We describe a further case of pneumonia in a patient with cystic fibrosis, and outline potential transmission of the organism from healthy family members to this patient. We review the evidence regarding the pathogenicity of PVL toxin with a special reference to patients with cystic fibrosis. We outline current concerns regarding the potential transmission of the organism and possible treatment strategies. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：22 / 25
页数：4
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