Nonalcoholic steatohepatitis: pathologic features and differential diagnosis

被引:61
作者
Brunt, Elizabeth M. [1 ]
机构
[1] St Louis Univ, Sch Med, Ctr Liver, St Louis, MO USA
关键词
nonalcoholic; fatty liver disease; steatohepatitis;
D O I
10.1053/j.semdp.2006.04.002
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
The worldwide epidemic of obesity has raised the awareness of nonalcoholic fatty liver disease (NAFLD) from that of a curiosity to one of a potentially progressive liver disease with risk for cirrhosis and hepatocellular carcinoma. This overview is focused on the histopathology of the spectrum of fatty liver disease, and discusses the role of liver biopsy, differential diagnoses, and new techniques in development. When pertinent, pathophysiology of this metabolic liver disease and recent treatment considerations have been mentioned as well. (C) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:330 / 338
页数:9
相关论文
共 93 条
[1]   2 CASES FROM THE SPECTRUM OF NONALCOHOLIC STEATOHEPATITIS [J].
ABDELMALEK, M ;
LUDWIG, J ;
LINDOR, KD .
JOURNAL OF CLINICAL GASTROENTEROLOGY, 1995, 20 (02) :127-130
[2]   The bulge, booze, and the liver [J].
Adams, LA ;
Angulo, P .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2005, 3 (12) :1195-1197
[3]   Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis [J].
Angulo, P ;
Keach, JC ;
Batts, KP ;
Lindor, KD .
HEPATOLOGY, 1999, 30 (06) :1356-1362
[4]   Nonalcoholic fatty liver disease [J].
Brunt, Elizabeth M. ;
Wong, Vincent W. -S. ;
Nobili, Valerio ;
Day, Christopher P. ;
Sookoian, Silvia ;
Maher, Jacquelyn J. ;
Bugianesi, Elisabetta ;
Sirlin, Claude B. ;
Neuschwander-Tetri, BrentA. ;
Rinella, Mary E. .
NATURE REVIEWS DISEASE PRIMERS, 2015, 1
[5]   NONALCOHOLIC STEATOHEPATITIS - AN EXPANDED CLINICAL ENTITY [J].
BACON, BR ;
FARAHVASH, MJ ;
JANNEY, CG ;
NEUSCHWANDERTETRI, BA .
GASTROENTEROLOGY, 1994, 107 (04) :1103-1109
[6]   Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos Nutrition and Liver Study [J].
Bedogni, G ;
Miglioli, L ;
Masutti, F ;
Tiribelli, C ;
Marchesini, G ;
Bellentani, S .
HEPATOLOGY, 2005, 42 (01) :44-52
[7]   Hepatocellular carcinoma without cirrhosis in a patient with nonalcoholic steatohepatitis [J].
Bencheqroun, R ;
Duvoux, C ;
Luciani, A ;
Zafrani, ES ;
Dhumeaux, D .
GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE, 2004, 28 (05) :497-499
[8]   Ethnic differences in the prevalence of cryptogenic cirrhosis [J].
Browning, JD ;
Kumar, KS ;
Saboorian, H ;
Thiele, DL .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2004, 99 (02) :292-298
[9]   Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity [J].
Browning, JD ;
Szczepaniak, LS ;
Dobbins, R ;
Nuremberg, P ;
Horton, JD ;
Cohen, JC ;
Grundy, SM ;
Hobbs, HH .
HEPATOLOGY, 2004, 40 (06) :1387-1395
[10]  
Brunt Elizabeth M, 2002, Clin Liver Dis, V6, P399, DOI 10.1016/S1089-3261(02)00002-8