A bifunctional ligand enables efficient gold-catalyzed hydroarylation of terminal unactivated propargylic alcohols with heteroareneboronic acids

被引：3
作者：
Liao, Shengrong [1 ,2 ]
Xu, Huayan [1 ,2 ]
Xu, Liang [1 ,2 ]
Liang, Baoxia [3 ]
Yang, Bin [1 ,2 ]
Wang, Junfeng [1 ,2 ]
Zhou, Xuefeng [1 ,2 ]
Lin, Xiuping [1 ,2 ]
Luo, Zaigang [4 ]
Liu, Yonghong [1 ,2 ]
机构：
[1] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, Res Ctr Marine Microbes,Guangdong Key Lab Marine, Guangzhou 510301, Peoples R China
[2] Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China
[3] Guangzhou Med Univ, Dept Radiol, Affiliated Hosp 2, Guangzhou 510260, Peoples R China
[4] Anhui Univ Sci & Technol, Coll Chem Engn, Huainan 232001, Peoples R China
来源：
TETRAHEDRON | 2021年 / 77卷
基金：
中国国家自然科学基金;
关键词：
Gold catalysis; Bifunctional ligand; Hydroarylation; Propargylic alcohol; Boronic acid; ARYLBORONIC ACIDS; ALKYNES; ISOMERIZATION; FUNCTIONALIZATION; HYDROALLYLATION; BONDS; MILD;
D O I：
10.1016/j.tet.2020.131764
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Terminal allylic alcohols are important motifs in natural products, and also key intermediates/precursors in numerous novel reaction transformations. In this study, enabled by a bifunctional ligand featuring a basic amino group, a gold-catalyzed hydroarylation of terminal unactivated propargylic alcohols with heteroareneboronic acids has been first established, and efficiently affords various terminal aryl-substituted allylic alcohols with moderate to high yields under mild conditions. (C) 2020 Elsevier Ltd. All rights reserved.
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页数：9
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