A bifunctional ligand enables efficient gold-catalyzed hydroarylation of terminal unactivated propargylic alcohols with heteroareneboronic acids

被引：3

作者：

Liao, Shengrong ^{[1
,2
]}

Xu, Huayan ^{[1
,2
]}

Xu, Liang ^{[1
,2
]}

Liang, Baoxia ^{[3
]}

Yang, Bin ^{[1
,2
]}

Wang, Junfeng ^{[1
,2
]}

Zhou, Xuefeng ^{[1
,2
]}

Lin, Xiuping ^{[1
,2
]}

Luo, Zaigang ^{[4
]}

Liu, Yonghong ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, South China Sea Inst Oceanol, Res Ctr Marine Microbes,Guangdong Key Lab Marine, Guangzhou 510301, Peoples R China

[2] Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China

[3] Guangzhou Med Univ, Dept Radiol, Affiliated Hosp 2, Guangzhou 510260, Peoples R China

[4] Anhui Univ Sci & Technol, Coll Chem Engn, Huainan 232001, Peoples R China

来源：

TETRAHEDRON | 2021年 / 77卷

基金：

中国国家自然科学基金;

关键词：

Gold catalysis; Bifunctional ligand; Hydroarylation; Propargylic alcohol; Boronic acid; ARYLBORONIC ACIDS; ALKYNES; ISOMERIZATION; FUNCTIONALIZATION; HYDROALLYLATION; BONDS; MILD;

D O I：

10.1016/j.tet.2020.131764

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Terminal allylic alcohols are important motifs in natural products, and also key intermediates/precursors in numerous novel reaction transformations. In this study, enabled by a bifunctional ligand featuring a basic amino group, a gold-catalyzed hydroarylation of terminal unactivated propargylic alcohols with heteroareneboronic acids has been first established, and efficiently affords various terminal aryl-substituted allylic alcohols with moderate to high yields under mild conditions. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：9

共 38 条

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