TGF-β signaling and the development of osteoarthritis

被引：203
作者：
Shen, Jie [1 ]
Li, Shan [2 ]
Chen, Di [2 ]
机构：
[1] Univ Rochester, Sch Med, Ctr Musculoskeletal Res, Dept Orthopaed & Rehabil, Rochester, NY 14642 USA
[2] Rush Univ, Med Ctr, Dept Biochem, Chicago, IL 60612 USA
来源：
BONE RESEARCH | 2014年 / 2卷
关键词：
GROWTH-FACTOR-BETA; MESENCHYMAL STEM-CELLS; MURINE KNEE-JOINT; BONE MORPHOGENETIC PROTEIN; ACID REPEAT POLYMORPHISM; OSTEOPHYTE FORMATION; ARTICULAR-CARTILAGE; CHONDROCYTE DIFFERENTIATION; TRANSGENIC MICE; GENE;
D O I：
10.1038/boneres.2014.2
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Osteoarthritis (OA) is a common joint degenerative disease affecting the whole joint structure, including articular cartilage, subchondral bone and synovial tissue. Although extensive work has been done in recent years to explore the molecular mechanism underlying this disease, the pathogenesis of OA is still poorly understood and currently, there is no effective disease-modifying treatment for OA. Recently, both in vitro and in vivo studies suggest that confirmed (TGF-beta)/SMAD pathway plays a critical role during OA development. This short review will focus on the function and signaling mechanisms of TGF-beta/SMAD pathway in articular chondrocytes, mesenchymal progenitor cells of subchondral bone and synovial lining cells during OA development.
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页数：7
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