Contrast enhanced ultrasound in mixed hepatocellular cholangiocarcinoma: Case series and review of the literature

被引：21

作者：

Dong, Yi ^{[1
]}

Teufel, Andreas ^{[2
]}

Trojan, Joerg ^{[3
]}

Berzigotti, Annalisa ^{[4
]}

Cui, Xin Wu ^{[5
]}

Dietrich, Christoph F. ^{[6
]}

机构：

[1] Fudan Univ, Zhongshan Hosp, Dept Ultrasound, Shanghai 200032, Peoples R China

[2] Heidelberg Univ, Med Fac Mannheim, Dept Med 2, Div Hepatol, Heidelberg, Germany

[3] Johann Wolfgang Goethe Univ Klinikum, Med Dept 1, Frankfurt, Germany

[4] Univ Bern, Inselspital, Univ Clin Visceral Surg & Med, Hepatol, Bern, Switzerland

[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Med Ultrasound, Wuhan, Hubei, Peoples R China

[6] Caritas Krankenhaus Bad Mergentheim, Med Dept 2, D-97980 Bad Mergentheim, Germany

来源：

DIGESTIVE AND LIVER DISEASE | 2018年 / 50卷 / 04期

关键词：

Contrast-enhanced ultrasound (CEUS); Diagnosis; Differentiate; Mixed hepatocellular cholangiocarcinoma (HCC-CCA); CLINICAL-PRACTICE RECOMMENDATIONS; PROCEDURES LONG VERSION; PRIMARY LIVER-CANCER; INTERVENTIONAL ULTRASOUND; EFSUMB GUIDELINES; CLINICOPATHOLOGICAL FEATURES; INTRAHEPATIC CHOLANGIOCARCINOMA; AMERICAN-COLLEGE; UPDATE; 2012; CARCINOMA;

D O I：

10.1016/j.dld.2017.11.003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Mixed hepatocellular cholangiocarcinoma is a rare form of primary liver cancer. Aims: The aim of this study is to report the results of the use of contrast enhanced ultrasound in a series of patients with confirmed mixed hepatocellular cholangiocarcinoma and to provide an updated literature review. Methods: Between January 2012 and October 2016, 25 Asian patients with confirmed mixed hepatocellular cholangiocarcinoma were included in this bicentric retrospective analysis. Clinical data as well recorded images of a standardized conventional B-mode ultrasound and contrast-enhanced ultrasound examination were interpreted by two blinded, independent, experienced radiologists in consensus. Results: All mixed hepatocellular cholangiocarcinoma lesions were heteroechoic on B-mode ultrasound, with ill-defined margins and irregular shapes. Arterial phase hyperenhancement was present in all 25 patients. Late-phase washout and hypoenhancement was present in 24/25 (96%) patients. However, rim enhancement and early wash-out (which are common in cholangiocellular carcinoma) were found in over 60% of the cases. Conclusion: Contrast-enhanced ultrasound demonstrated findings not typical for HCC in a large proportion of patients with confirmed mixed hepatocellular cholangiocarcinoma. Therefore, histological confirmation is crucial, especially in lesions with atypical findings. (C) 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：401 / 407

页数：7

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