Phytosterols as a natural anticancer agent: Current status and future perspective

被引：198

作者：

Shahzad, Naiyer ^{[1
]}

Khan, Wajahatullah ^{[2
]}

Shadab, M. D. ^{[3
]}

Ali, Asgar ^{[4
]}

Saluja, Sundeep Singh ^{[5
]}

Sharma, Sadhana ^{[4
]}

Al-Allaf, Faisal A. ^{[6
]}

Abduljaleel, Zainularifeen ^{[6
]}

Ibrahim, Ibrahim Abdel Aziz ^{[1
]}

Abdel-Wahab, Ali Fathi ^{[1
]}

Afify, Mohamed Abdelaziz ^{[1
]}

Al-Ghamdi, Saeed Saeed ^{[1
]}

机构：

[1] Umm Al Qura Univ, Fac Med, Dept Pharmacol & Toxicol, POB 7182, Mecca 21955, Saudi Arabia

[2] King Saud Bin Abdul Aziz Univ Hlth Sci, Dept Basic Sci, Coll Sci & Hlth Profess, Riyadh, Saudi Arabia

[3] Int Med Univ, Sch Pharm, Dept Pharmaceut Technol, Kuala Lumpur, Malaysia

[4] AIIMS, Dept Biochem, Patna, Bihar, India

[5] GB Pant Hosp, Dept GI Surg, New Delhi, India

[6] Umm Al Qura Univ, Fac Med, Dept Med Genet, Mecca, Saudi Arabia

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2017年 / 88卷

关键词：

Phytosterols; Dietary phytosterols; Phytosterols and cancer; Campesterol; Anticancer effect of sterols; Dietary phytosterols and cancer; DIETARY PLANT STEROLS; BREAST-CANCER CELLS; BENIGN PROSTATIC HYPERPLASIA; BETA-SITOSTEROL GLUCOSIDE; BLIND CLINICAL-TRIAL; ALKALINE SPHINGOMYELINASE; CHOLESTEROL ABSORPTION; PROTEIN PHOSPHATASE; FATTY-ACID; IN-VITRO;

D O I：

10.1016/j.biopha.2017.01.068

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Phytosterols are naturally occurring compounds in plants, structurally similar to cholesterol. The human diet is quite abundant in sitosterol and campesterol. Phytosterols are known to have various bioactive properties including reducing intestinal cholesterol absorption which alleviates blood LDL-cholesterol and cardiovascular problems. It is indicated that phytosterol rich diets may reduce cancer risk by 20%. Phytosterols may also affect host systems, enabling antitumor responses by improving immune response recognition of cancer, affecting the hormone dependent endocrine tumor growth, and by sterol biosynthesis modulation. Moreover, phytosterols have also exhibited properties that directly inhibit tumor growth, including reduced cell cycle progression, apoptosis induction, and tumor metastasis inhibition. The objective of this review is to summarize the current knowledge on occurrences, chemistry, pharmacokinetics and potential anticancer properties of phytosterols in vitro and in vivo. In conclusion, anticancer effects of phytosterols have strongly been suggested and support their dietary inclusion to prevent and treat cancers. (C) 2017 Published by Elsevier Masson SAS.

引用

页码：786 / 794

页数：9

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