Lipase catalyzed ascorbyl palmitate synthesis under microwave irradiation

被引：21
作者：
Costa, Ingrid C. R. [1 ,2 ]
Sutili, Felipe K. [1 ,2 ]
da Silva, Gabriela V. V. [2 ]
Leite, Selma G. F. [1 ]
Miranda, Leandro S. M. [2 ]
de Souza, Rodrigo O. M. A. [2 ]
机构：
[1] Univ Fed Rio de Janeiro, Escola Quim, BR-22941909 Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Inst Quim, Lab Biocatalise & Sintese Organ, BR-21941909 Rio De Janeiro, RJ, Brazil
来源：
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2014年 / 102卷
关键词：
Microwave irradiation; Lipases; Ascorbyl palmitate; Ascorbic acid; Palmitic acid; ENZYMATIC-SYNTHESIS; ACID; ESTER;
D O I：
10.1016/j.molcatb.2014.02.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The production of ascorbyl palmitate from palmitic acid and ascorbic acid through the esterification catalyzed by Novozym 435 was performed under microwave irradiation. The effects of different reaction parameters were evaluated. The reactions were carried out in organic solvent (acetone, tert-amyl alcohol, cyclohexane, acetonitrile) and the results show that tert-amyl alcohol was the best solvent for this reaction. Parameters as temperature, molar ratio and enzyme loading were evaluated through a central composite design (CCD). In the optimized conditions, 15% (w/w in relation of ascorbic acid weight) of enzyme, 70 degrees C and molar ratio 1:5, 71% yield of ascorbyl palmitate could be achieved after 1 h. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：127 / 131
页数：5
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