Schiff bases of methanesulfonylhydrazine.: Synthesis, spectroscopic characterization, conformational analysis, and biological activity

被引：0
|
作者：
Dodoff, NI
Özdemir, Ü
Karacan, N
Georgieva, MC
Konstantinov, SM
Stefanova, ME
机构：
[1] Bulgarian Acad Sci, Inst Mol Biol, BU-1113 Sofia, Bulgaria
[2] Gazi Univ, Fac Sci & Art, Dept Chem, TR-06500 Ankara, Turkey
[3] Natl Oncol Ctr, Lab Oncogenesis, Sofia 1756, Bulgaria
[4] Med Univ Sofia, Fac Pharm, Dept Pharmacol & Toxicol, Sofia 1000, Bulgaria
[5] Bulgarian Acad Sci, Inst Microbiol, BU-1113 Sofia, Bulgaria
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 1999年 / 54卷 / 12期
关键词：
Schiff bases; methanesulfonylhydrazine; H-1 NMR data; molecular mechanics; cytotoxic activity;
D O I：
暂无
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Three novel Schiff bases: salicylaldehyde methanesulfonylhydrazone (1), 2-hydroxyacetophenone methanesulfonylhydrazone (2) and 2-hydroxy-1-naphthaldehyde methanesulfonylhydrazone (3) have been synthesized. Compounds 1-3, as well as acetone methanesulfonylhydrazone (4) have been characterized by TLC, H-1 NMR and IR spectra. The spectroscopic results for 1-3 have revealed the presence of an intramolecular hydrogen bond between the hydroxyl group and the imine N atom. The conformational isomerism of 1-4 with respect to the rotations around the SN and NN bonds have been studied by the method of molecular mechanics. Compounds 1-4 and methanesulfonylhydrazine exhibit antibacterial and cytotoxic effects.
引用
收藏
页码：1553 / 1562
页数：10
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