Mixed Valence Copper(I,II) Binuclear Complexes with Unexpected Structure: Synthesis, Biological Properties and Anticancer Activity

被引：74

作者：

Majouga, Alexander G. ^{[1
,6
]}

Zvereva, Maria I. ^{[1
,2
]}

Rubtsova, Maria P. ^{[1
,2
]}

Skvortsov, Dmitry A. ^{[1
]}

Mironov, Andrei V. ^{[1
]}

Azhibek, Dulat M. ^{[1
,7
]}

Krasnovskaya, Olga O. ^{[1
]}

Gerasimov, Vasily M. ^{[1
]}

Udina, Anna V. ^{[1
]}

Vorozhtsov, Nikolay I. ^{[1
]}

Beloglazkina, Elena K. ^{[1
]}

Agron, Leonid ^{[1
]}

Mikhina, Larisa V. ^{[5
]}

Tretyakova, Alla V. ^{[5
]}

Zyk, Nikolay V. ^{[1
]}

Zefirov, Nikolay S. ^{[1
]}

Kabanov, Alexander V. ^{[1
,3
,4
]}

Dontsova, Olga A. ^{[1
,2
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia

[2] Moscow MV Lomonosov State Univ, Belozersky Inst, Moscow 119992, Russia

[3] Univ N Carolina, Ctr Nanotechnol Drug Delivery, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

[4] Univ N Carolina, Div Mol Pharmaceut, Eshelman Sch Pharm, Chapel Hill, NC 27599 USA

[5] Fed Medicobiol Agcy, Fed State Financed Inst Res Ctr Toxicol & Hygien, Serpukhov 142253, Moscow Region, Russia

[6] Natl Univ Sci & Technol MISiS, Moscow 119049, Russia

[7] Skolkovo Inst Sci & Technol, Skolkovo 143025, Russia

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 57卷 / 14期

基金：

俄罗斯基础研究基金会;

关键词：

IN-VITRO; TELOMERASE; CELLS; TOXICITY; BINDING; DNA; DERIVATIVES; APOPTOSIS; COMPOUND; CANCER;

D O I：

10.1021/jm500154f

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have synthesized and characterized a panel of new binuclear mixed valence Cu(I,II) complexes containing substituted 2-alkylthio-5-arylmethylene-4H-imidazolin-4-ones with unusual structure. These complexes are shown to be cytotoxic for various cell lines. We have found that these compounds did not intercalate DNA, inhibited number of polymerases (telomerase predominantly), accumulated in the cell nucleus, and caused DNA degradation. Preliminary studies revealed that lead compound inhibited human breast adenocarcinoma growth in mice model.

引用

页码：6252 / 6258

页数：7

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