From airway inflammation to inflammatory bowel disease: Eotaxin-1, a key regulator of intestinal inflammation

被引：63

作者：

Adar, Tomer ^{[1
]}

Shteingart, Shimon ^{[1
]}

Ben Ya'acov, Anni ^{[1
]}

Shitrit, Ariella Bar-Gil ^{[1
]}

Goldin, Eran ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Sch Med, Shaare Zedek Med Ctr, Inst Digest Dis, IL-91010 Jerusalem, Israel

来源：

CLINICAL IMMUNOLOGY | 2014年 / 153卷 / 01期

关键词：

Eotaxin; Eosinophil; Inflammatory bowel disease; Immune system; CHEMOKINE RECEPTOR CCR3; EOSINOPHIL CHEMOATTRACTANT CYTOKINE; SMOOTH-MUSCLE-CELLS; FUNCTIONAL EXPRESSION; MOLECULAR-CLONING; ULCERATIVE-COLITIS; GENE-EXPRESSION; MESSENGER-RNA; UP-REGULATION; CHEMOTACTIC ACTIVITY;

D O I：

10.1016/j.clim.2014.04.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Eotaxin-1 (CCL-11) is a potent eosinophil chemoattractant that is considered a major contributor to tissue eosinophilia. Elevated eotaxin-1 levels have been described in various pathologic conditions, ranging from airway inflammation, to Hodgkin lymphoma, obesity and coronary artery disease. The main receptor for eotaxin-1 is CCR3; however, recent evidence indicates that eotaxin-1 may also bind to other receptors expressed by various cell types, suggesting a more widespread regulatory role for eotaxin-1 beyond the recruitment of eosinophils. Eotaxin-1 is also strongly associated with various gastrointestinal (GI) disorders. Although the etiology of inflammatory bowel disease (IBD) is still unknown, eotaxin-1 may play a key role in the development of mucosal inflammation. In this review, we summarize the biological context and effects of eotaxin-1, as well as its potential role as a therapeutic target, with a special focus on gastrointestinal inflammation. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：199 / 208

页数：10

共 104 条

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