Proteomic analysis of adipose tissue: informing diabetes research

被引：12

作者：

Murri, Mora ^{[1
,2
,3
,4
]}

Insenser, Maria ^{[1
,2
,3
,4
]}

Luque, Manuel ^{[1
,2
,3
,4
]}

Tinahones, Francisco J. ^{[5
,6
]}

Escobar-Morreale, Hector F. ^{[1
,2
,3
,4
]}

机构：

[1] Hosp Univ Ramon & Cajal, Dept Endocrinol & Nutr, Diabet Obes & Human Reprod Res Grp, E-28034 Madrid, Spain

[2] Univ Alcala, E-28034 Madrid, Spain

[3] IRYCIS, E-28034 Madrid, Spain

[4] Ctr Invest Biomed Red Diabet & Enfermedades Metab, E-28034 Madrid, Spain

[5] HCU Virgen de la Victoria, Serv Endocrinol & Nutr, Malaga 29010, Spain

[6] Ctr Invest Biomed Red Hsiopatol Obesidad & Nutr C, Malaga 29010, Spain

来源：

EXPERT REVIEW OF PROTEOMICS | 2014年 / 11卷 / 04期

关键词：

adipose tissue; diabetes; gestational diabetes; insulin resistance; proteomics; Type; 2; INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; GAMMA-SYNUCLEIN; INFLAMMATION; OBESITY; ADIPOCYTE; PROTEINS; HEAT-SHOCK-PROTEIN-60; PATHOGENESIS;

D O I：

10.1586/14789450.2014.903158

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetes, one of the most common endocrine diseases worldwide, results from complex pathophysiological mechanisms that are not fully understood. Adipose tissue is considered a major endocrine organ and plays a central role in the development of diabetes. The identification of the adipose tissue-derived factors that contribute to the onset and progression of diabetes will hopefully lead to the development of preventive and therapeutic interventions. Proteomic techniques may be useful tools for this purpose. In the present review, we have summarized the studies conducting adipose tissue proteomics in subjects with diabetes and insulin resistance, and

引用

页码：491 / 502

页数：12

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