A novel resolution procedure for the preparation of P-stereogenic phosphine oxides

被引：25
|
作者：
Andersen, NG [1 ]
Ramsden, PD [1 ]
Che, DQ [1 ]
Parvez, M [1 ]
Keay, BA [1 ]
机构：
[1] Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada
来源：
ORGANIC LETTERS | 1999年 / 1卷 / 12期
关键词：
D O I：
10.1021/ol991174s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] A new general route for preparing enantiomerically pure P-stereogenic phosphine oxides has been developed by exploiting the Staudinger reaction between racemic tertiary phosphines and an enantiomerically pure organoazide. The resulting phosphinimines are easily resolved by either crystallization or flash chromatography and serve as synthetic intermediates toward enantiomerically pure phosphine oxides.
引用
收藏
页码：2009 / 2011
页数：3
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