Transformation of astragalosides from Radix Astragali under acidic, neutral, and alkaline extraction conditions monitored by LC-ESI-TOF/MS

被引：16
作者：
Chu Chu [1 ]
Liu E-Hu [1 ]
Qi Lian-Wen [1 ]
Li Ping [1 ]
机构：
[1] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2014年 / 12卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Transformation; Radix Astragali; LC-TOF/MS; Astragalosides; SAPONINS; HPLC; ANTIOXIDANT; FLAVONOIDS; PRODUCTS; SAMPLES; GROWTH;
D O I：
10.1016/S1875-5364(14)60062-5
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
AIM: To reveal the profile of astragalosides for better quality evaluation of Radix Astragali, this study was aimed to investigate the transformation of astragalosides under different conditions. METHOD: Seven major astragalosides were selected for evaluation under acidic, neutral and alkaline conditions. The transformation in real plant samples was also examined and the products were characterized by LC-ESI-TOF/MS. RESULTS: In weak acidic solution, all of the astragalosides are stable. In addition, the transformation ratios of the astragalosides under neutral and alkaline conditions were also obtained. CONCLUSION: In neutral solution, malonylastragaloside I was transformed to astragaloside I; and in alkaline solution, substituent group(s) in the xylose moiety of all the astragalosides were eliminated. Since astragalosdie IV is the basic skeleton structure of the astrgalosides, it is a common transformation product of other astragalosides.
引用
收藏
页码：314 / 320
页数：7
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