The small members of the JMJD protein family: Enzymatic jewels or jinxes?

被引：47

作者：

Oh, Sangphil ^{[1
,2
]}

Shin, Sook ^{[1
,2
]}

Janknecht, Ralf ^{[1
,2
,3
]}

机构：

[1] Univ Oklahoma, Dept Cell Biol, Hlth Sci Ctr, Oklahoma City, OK 73104 USA

[2] Univ Oklahoma, Stephenson Canc Ctr, Hlth Sci Ctr, Oklahoma City, OK 73104 USA

[3] Univ Oklahoma, Dept Pathol, Hlth Sci Ctr, Oklahoma City, OK 73104 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2019年 / 1871卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Cancer; Demethylation; Hydroxylation; Jumonji; Oncometabolite; DOMAIN-CONTAINING PROTEIN; MYC TARGET GENE; FACTOR-INHIBITING HIF; H3K36ME2 HISTONE DEMETHYLASE; HYPOXIA-INDUCIBLE FACTOR; PHOSPHATIDYLSERINE RECEPTOR; CRYSTAL-STRUCTURE; ONCOMETABOLITE; 2-HYDROXYGLUTARATE; ARGININE METHYLATION; NUCLEAR-LOCALIZATION;

D O I：

10.1016/j.bbcan.2019.04.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Jumonji C domain-containing (JMJD) proteins are mostly epigenetic regulators that demethylate histones. However, a hitherto neglected subfamily of JMJD proteins, evolutionarily distant and characterized by their relatively small molecular weight, exerts different functions by hydroxylating proteins and RNA. Recently, unsuspected proteolytic and tyrosine kinase activities were also ascribed to some of these small JMJD proteins, further increasing their enzymatic versatility. Here, we discuss the ten human small JMJD proteins (HIF1AN, HSPBAP1, JMJD4, JMJD5, JMJD6, JMJD7, JMJD8, RIOX1, RIOX2, TYW5) and their diverse physiological functions. In particular, we focus on the roles of these small JMJD proteins in cancer and other maladies and how they are modulated in diseased cells by an altered metabolic milieu, including hypoxia, reactive oxygen species and oncometabolites. Because small JMJD proteins are enzymes, they are amenable to inhibition by small molecules and may represent novel targets in the therapy of cancer and other diseases.

引用

页码：406 / 418

页数：13

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