Effectiveness and safety as outcome measures in reproductive medicine

被引：23

作者：

Braakhekke, M. ^{[1
]}

Kamphuis, E. I. ^{[1
]}

Mol, F. ^{[1
]}

Norman, R. J. ^{[2
]}

Bhattacharya, S. ^{[3
]}

van der Veen, F. ^{[1
]}

Mol, B. W. J. ^{[2
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Ctr Reprod Med, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Adelaide, Sch Paediat & Reprod Hlth, Robinson Res Inst, Adelaide, SA, Australia

[3] Univ Aberdeen, Div Appl Hlth Sci, Reprod Med, Aberdeen, Scotland

来源：

HUMAN REPRODUCTION | 2015年 / 30卷 / 10期

关键词：

effectiveness; safety; outcome measures; reproductive medicine; SINGLE-EMBRYO-TRANSFER; ASSISTED REPRODUCTION; RELEVANT STANDARD; SUCCESS;

D O I：

10.1093/humrep/dev201

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The aim of reproductive medicine is to help couples with an unfulfilled child wish to have a child by offering them the best treatment option. The choice of treatment reflects effectiveness and safety. While effectiveness refers to the extent to which a treatment increases the chance of a couple in having a baby, safety relates to adverse effects associated with such a treatment. In an attempt to integrate effectiveness and safety, healthy singleton live birth (at term) has been suggested as the ideal outcome measure for evaluative research in reproductive medicine. Although intuitively desirable, this proposal overlooks the fact that assessment of effectiveness and safety in this context cannot be measured as a single outcome. In this paper, we explain why effectiveness and safety outcomes in reproductive medicine should be assessed independently, and later synthesized to inform clinical decision-making.

引用

页码：2249 / 2251

页数：3

共 10 条

[1] Obstetrical outcome valuations by patients, professionals, and laypersons: differences within and between groups using three valuation methods [J].

Bijlenga, Denise ;

Birnie, Erwin ;

Mol, Ben W. J. ;

Bonsel, Gouke J. .

BMC PREGNANCY AND CHILDBIRTH, 2011, 11

[2]

Dancet EAF, 2014, FERTIL STERIL, V101, P924, DOI 10.1016/j.fertnstert.2013.12.045

[3] Users' Guides to The Medical Literature - XXV. Evidence-based medicine: Principles for applying the Users' Guides to patient care [J].

Guyatt, GH ;

Haynes, RB ;

Jaeschke, RZ ;

Cook, DJ ;

Green, L ;

Naylor, CD ;

Wilson, MC ;

Richardson, WS .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 284 (10) :1290-1296

[4] Randomized single versus double embryo transfer: obstetric and paediatric outcome and a cost-effectiveness analysis [J].

Kjellberg, AT ;

Carlsson, P ;

Bergh, C .

HUMAN REPRODUCTION, 2006, 21 (01) :210-216

[5]

Land J. A., 2003, Human Reproduction (Oxford), V18, P455, DOI 10.1093/humrep/deg081

[6] Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome [J].

Legro, Richard S. ;

Brzyski, Robert G. ;

Diamond, Michael P. ;

Coutifaris, Christos ;

Schlaff, William D. ;

Casson, Peter ;

Christman, Gregory M. ;

Huang, Hao ;

Yan, Qingshang ;

Alvero, Ruben ;

Haisenleder, Daniel J. ;

Barnhart, Kurt T. ;

Bates, G. Wright ;

Usadi, Rebecca ;

Lucidi, Scott ;

Baker, Valerie ;

Trussell, J. C. ;

Krawetz, Stephen A. ;

Snyder, Peter ;

Ohl, Dana ;

Santoro, Nanette ;

Eisenberg, Esther ;

Zhang, Heping .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (02) :119-129

[7] What is the most relevant standard of success in assisted reproduction? The singleton, term gestation, live birth rate per cycle initiated: the BESST endpoint for assisted reproduction [J].

Min, JK ;

Breheny, SA ;

MacLachlan, V ;

Healy, DL .

HUMAN REPRODUCTION, 2004, 19 (01) :3-7

[8] Safety versus success in elective single embryo transfer:: women's preferences for outcomes of in vitro fertilisation [J].

Scotland, G. S. ;

McNamee, P. ;

Peddie, V. L. ;

Bhattacharya, S. .

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2007, 114 (08) :977-983

[9] Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization [J].

Thurin, A ;

Hausken, J ;

Hillensjö, T ;

Jablonowska, B ;

Pinborg, A ;

Strandell, A ;

Bergh, C .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (23) :2392-2402

[10] What is the most relevant standard of success in assisted reproduction? Singleton live births should also include preterm births [J].

Wennerholm, UB ;

Bergh, C .

HUMAN REPRODUCTION, 2004, 19 (09) :1943-1945

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