Analysis of inflammatory cytokines and estimated glomerular filtration rate decline in Japanese patients with diabetic kidney disease: a pilot study

被引：2
作者：
Sugawara, Yuka [1 ]
Hirakawa, Yosuke [1 ]
Mise, Koki [2 ]
Kashiwabara, Kosuke [3 ]
Hanai, Ko [4 ]
Yamaguchi, Satoshi [2 ]
Katayama, Akihiro [2 ]
Onishi, Yasuhiro [2 ]
Yoshida, Yui [1 ]
Kashihara, Naoki [5 ]
Matsuyama, Yutaka [6 ]
Babazono, Tetsuya [4 ]
Nangaku, Masaomi [1 ]
Wada, Jun [2 ]
机构：
[1] Univ Tokyo, Div Nephrol & Endocrinol, Grad Sch Med, Tokyo 1138655, Japan
[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Nephrol Rheumatol Endocrinol & Metab, Okayama 7008558, Japan
[3] Univ Tokyo Hosp, Clin Res Promot Ctr, Data Sci Off, Tokyo 1138655, Japan
[4] Tokyo Womens Med Univ, Diabet Ctr, Sch Med, Tokyo 1628666, Japan
[5] Kawasaki Med Sch, Dept Nephrol & Hypertens, Kurashiki, Okayama 7010192, Japan
[6] Univ Tokyo, Dept Biostat, Tokyo 1130033, Japan
来源：
BIOMARKERS IN MEDICINE | 2022年 / 16卷 / 10期
关键词：
biomarkers; cytokines; diabetic kidney disease; glomerular filtration rate; prognosis; TUMOR-NECROSIS-FACTOR; BIOMARKERS; TWEAK; NEPHROPATHY; PROGRESSION; RISK;
D O I：
10.2217/bmm-2021-1104
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background: It is important to identify additional prognostic factors for diabetic kidney disease. Materials & methods: Baseline levels of ten cytokines (APRIL/TNFSF13, BAFF/TNFSF13B, chitinase 3-like 1, LIGHT/TNFSF14, TWEAK/TNFSF12, gp130/sIL-6R beta, sCD163, sIL-6R alpha, sTNF-R1, sTNF-R2) were measured in two cohorts of diabetic patients. In one cohort (n = 777), 156 individuals were randomly sampled after stratification and their plasma samples were analyzed; in the other cohort (n = 69), serum samples were analyzed in all the individuals. The levels of cytokines between rapid (estimated glomerular filtration rate decline >5 ml/min/1.73 m(2)/year) and non-rapid decliners were compared. Results: Multivariate analysis demonstrated significantly high levels of LIGHT/TNFSF14, TWEAK/TNFSF12 and sTNF-R2 in rapid decliners. Conclusion: These three cytokines can be potential biomarkers for the progression of diabetic kidney disease.
引用
收藏
页码：759 / 770
页数：12
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