Retrospective comparison of two consecutive cohorts of adjuvant chemotherapy regimens of cyclophosphamide with either docetaxel or paclitaxel in older patients with early breast cancer

被引：2
|
作者：
Joris, Sofie [1 ]
Fontaine, Christel [1 ]
Decoster, Lore [1 ]
Vanacker, Leen [1 ]
Schallier, Denis [1 ]
De Greve, Jacques [1 ]
机构：
[1] UZ Brussel, Oncol Ctr, Dept Med Oncol, Jette, Belgium
来源：
BREAST JOURNAL | 2019年 / 25卷 / 04期
关键词：
chemotherapy; breast cancer; elderly; FEBRILE NEUTROPENIA; DOCETAXEL/CYCLOPHOSPHAMIDE;
D O I：
10.1111/tbj.13306
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Adjuvant chemotherapy with docetaxel/cyclophosphamide (TC) is adopted worldwide as a valuable option for elderly patients with high-risk early breast cancer. Some studies suggest that paclitaxel may have a better therapeutic ratio than docetaxel. Therefore we have implemented an adjuvant chemotherapy in which docetaxel was replaced by paclitaxel. We report here the retrospective analysis of that cohort and make a safety comparison with an earlier TC cohort in the same target population. This retrospective analysis demonstrates the feasibility of paclitaxel/cyclophosphamide as an alternative, better tolerated adjuvant regimen for elderly patients. Further evaluation and assessment of noninferiority to TC is warranted.
引用
收藏
页码：663 / 666
页数：4
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