Retrospective comparison of two consecutive cohorts of adjuvant chemotherapy regimens of cyclophosphamide with either docetaxel or paclitaxel in older patients with early breast cancer

被引：2
|
作者：
Joris, Sofie [1 ]
Fontaine, Christel [1 ]
Decoster, Lore [1 ]
Vanacker, Leen [1 ]
Schallier, Denis [1 ]
De Greve, Jacques [1 ]
机构：
[1] UZ Brussel, Oncol Ctr, Dept Med Oncol, Jette, Belgium
来源：
BREAST JOURNAL | 2019年 / 25卷 / 04期
关键词：
chemotherapy; breast cancer; elderly; FEBRILE NEUTROPENIA; DOCETAXEL/CYCLOPHOSPHAMIDE;
D O I：
10.1111/tbj.13306
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Adjuvant chemotherapy with docetaxel/cyclophosphamide (TC) is adopted worldwide as a valuable option for elderly patients with high-risk early breast cancer. Some studies suggest that paclitaxel may have a better therapeutic ratio than docetaxel. Therefore we have implemented an adjuvant chemotherapy in which docetaxel was replaced by paclitaxel. We report here the retrospective analysis of that cohort and make a safety comparison with an earlier TC cohort in the same target population. This retrospective analysis demonstrates the feasibility of paclitaxel/cyclophosphamide as an alternative, better tolerated adjuvant regimen for elderly patients. Further evaluation and assessment of noninferiority to TC is warranted.
引用
收藏
页码：663 / 666
页数：4
相关论文
共 50 条
  • [1] Febrile neutropenia in adjuvant docetaxel and cyclophosphamide (TC) with prophylactic pegfilgrastim in breast cancer patients: a retrospective analysis
    Ngamphaiboon, Nuttapong
    O'Connor, Tracey L.
    Advani, Pooja P.
    Levine, Ellis G.
    Kossoff, Ellen B.
    MEDICAL ONCOLOGY, 2012, 29 (03) : 1495 - 1501
  • [2] Underutilisation of prophylactic G-CSF in breast cancer patients receiving adjuvant docetaxel/cyclophosphamide chemotherapy
    Ku, Minhee
    Je, Nam Kyung
    JOURNAL OF CHEMOTHERAPY, 2022, 34 (08) : 534 - 542
  • [3] Febrile neutropenia in adjuvant docetaxel and cyclophosphamide (TC) with prophylactic pegfilgrastim in breast cancer patients: a retrospective analysis
    Nuttapong Ngamphaiboon
    Tracey L. O’Connor
    Pooja P. Advani
    Ellis G. Levine
    Ellen B. Kossoff
    Medical Oncology, 2012, 29 : 1495 - 1501
  • [4] Feasibility Study of Docetaxel with Cyclophosphamide as Adjuvant Chemotherapy for Japanese Breast Cancer Patients
    Takabatake, Daisuke
    Taira, Naruto
    Hara, Fumikata
    Sien, Tadahiko
    Kiyoto, Sachiko
    Takashima, Seiki
    Aogi, Kenjiro
    Ohsumi, Shozo
    Doihara, Hiroyoshi
    Takashima, Shigemitu
    JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2009, 39 (08) : 478 - 483
  • [5] Use of Doxorubicin Plus Cyclophosphamide Followed by Docetaxel as Adjuvant Chemotherapy for Breast Cancer
    Livi, L.
    Meattini, I.
    Cardillo, C. De Luca
    Scotti, V.
    Agresti, B.
    Franzese, C.
    Sanchez, L.
    Nori, J.
    Bertocci, S.
    Cassani, S.
    Bianchi, S.
    Cataliotti, L.
    Biti, G.
    JOURNAL OF CHEMOTHERAPY, 2011, 23 (01) : 36 - 39
  • [6] Comparison of the effectiveness and toxicity of neoadjuvant chemotherapy regimens, capecitabine/epirubicin/cyclophosphamide vs 5-fluorouracil/epirubicin/cyclophosphamide, followed by adjuvant, capecitabine/docetaxel vs docetaxel, in patients with operable breast cancer
    Zhang, Minmin
    Wei, Wei
    Liu, Jianlun
    Yang, Huawei
    Jiang, Yi
    Tang, Wei
    Li, Qiuyun
    Liao, Xiaoming
    ONCOTARGETS AND THERAPY, 2016, 9 : 3443 - 3450
  • [7] Toxicity profile differences of adjuvant docetaxel/cyclophosphamide (TC) between Asian and Caucasian breast cancer patients
    Chow, L. W. C.
    Biganzoli, L.
    Leo, A. D.
    Kuroi, K.
    Han, H. S.
    Patel, J.
    Huang, C. S.
    Lu, Y. S.
    Zhu, L.
    Chow, C. Y. C.
    Loo, W. T. Y.
    Gluck, S.
    Toi, M.
    ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2017, 13 (06) : 372 - 378
  • [8] The cost-utility of adjuvant chemotherapy using docetaxel and cyclophosphamide compared with doxorubicin and cyclophosphamide in breast cancer
    Younis, T.
    Rayson, D.
    Skedgel, C.
    CURRENT ONCOLOGY, 2011, 18 (06) : E288 - E296
  • [9] Efficacy of Scalp Cooling in Preventing Chemotherapy-Induced Alopecia in Breast Cancer Patients Receiving Adjuvant Docetaxel and Cyclophosphamide Chemotherapy
    Cigler, Tessa
    Isseroff, Devora
    Fiederlein, Barbara
    Schneider, Sarah
    Chuang, Ellen
    Vandat, Linda
    Moore, Anne
    CLINICAL BREAST CANCER, 2015, 15 (05) : 332 - 334
  • [10] Retrospective comparisons of nanoparticle albumin-bound paclitaxel and docetaxel neoadjuvant regimens for breast cancer
    Li, Yan
    Chen, Xiang
    Zhu, Qiannan
    Chen, Rui
    Xu, Lu
    Li, Shuo
    Shi, Xiaoqing
    Xu, Haiping
    Xu, Yinggang
    Zhang, Weiwei
    Huang, Xiaofeng
    Zha, Xiaoming
    Wang, Jue
    NANOMEDICINE, 2021, 16 (05) : 391 - 400
12345