Methotrexate for inflammatory bowel disease: time for reconsideration

被引:8
作者
Nielsen, Ole Haagen [1 ]
Ainsworth, Mark Andrew [2 ]
Steenholdt, Casper [1 ]
机构
[1] Univ Copenhagen, Dept Gastroenterol, Herlev Hosp, Herlev, Denmark
[2] Odense Univ Hosp, Dept Gastroenterol & Hepatol, Odense, Denmark
关键词
Crohn's disease; biologics; inflammatory bowel disease; methotrexate; therapy; ulcerative colitis; IMMUNOMODULATOR; REMISSION; THERAPY; ANTIBODIES; INFLIXIMAB; PLACEBO;
D O I
10.1080/17474124.2019.1596797
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:407 / 409
页数:3
相关论文
共 20 条
[1]   Addition of an Immunomodulator to Infliximab Therapy Eliminates Antidrug Antibodies in Serum and Restores Clinical Response of Patients With Inflammatory Bowel Disease [J].
Ben-Horin, Shomron ;
Waterman, Matti ;
Kopylov, Uri ;
Yavzori, Miri ;
Picard, Orit ;
Fudim, Ella ;
Awadie, Halim ;
Weiss, Batia ;
Chowers, Yehuda .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2013, 11 (04) :444-447
[2]   PHARMACOKINETICS OF METHOTREXATE ADMINISTERED BY INTRAMUSCULAR AND SUBCUTANEOUS INJECTIONS IN PATIENTS WITH RHEUMATOID-ARTHRITIS [J].
BROOKS, PJ ;
SPRUILL, WJ ;
PARISH, RC ;
BIRCHMORE, DA .
ARTHRITIS AND RHEUMATISM, 1990, 33 (01) :91-94
[3]   Methotrexate Is Not Superior to Placebo for Inducing Steroid-Free Remission, but Induces Steroid-Free Clinical Remission in a Larger Proportion of Patients With Ulcerative Colitis [J].
Carbonnel, Franck ;
Colombel, Jean Frederic ;
Filippi, Jerome ;
Katsanos, Konstantinos H. ;
Peyrin-Biroulet, Laurent ;
Allez, Mathieu ;
Nachury, Maria ;
Novacek, Gottfried ;
Danese, Silvio ;
Abitbol, Vered ;
Bossa, Fabrizio ;
Moreau, Jacques ;
Bommelaer, Gilles ;
Bourreille, Arnaud ;
Fumery, Mathurin ;
Roblin, Xavier ;
Reinisch, Walter ;
Bouhnik, Yoram ;
Brixi, Hedia ;
Seksik, Philippe ;
Malamut, Georgia ;
Farkkila, Martti ;
Coulibaly, Baya ;
Dewit, Olivier ;
Louis, Edouard ;
Deplanque, Dominique ;
Michetti, Pierre ;
Sarter, Helene ;
Laharie, David .
GASTROENTEROLOGY, 2016, 150 (02) :380-+
[4]   Methotrexate-how does it really work? [J].
Chan, Edwin S. L. ;
Cronstein, Bruce N. .
NATURE REVIEWS RHEUMATOLOGY, 2010, 6 (03) :175-178
[5]   Novel Targeted Therapies for Inflammatory Bowel Disease [J].
Coskun, Mehmet ;
Vermeire, Severine ;
Nielsen, Ole Haagen .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2017, 38 (02) :127-142
[6]   Pharmacology and Optimization of Thiopurines and Methotrexate in Inflammatory Bowel Disease [J].
Coskun, Mehmet ;
Steenholdt, Casper ;
de Boer, Nanne K. ;
Nielsen, Ole Haagen .
CLINICAL PHARMACOKINETICS, 2016, 55 (03) :257-274
[7]   A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease [J].
Feagan, BG ;
Fedorak, RN ;
Irvine, EJ ;
Wild, G ;
Sutherland, L ;
Steinhart, AH ;
Greenberg, GR ;
Koval, J ;
Wong, CJ ;
Hopkins, M ;
Hanauer, SB ;
McDonald, JWD .
NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (22) :1627-1632
[8]   METHOTREXATE FOR THE TREATMENT OF CROHNS-DISEASE [J].
FEAGAN, BG ;
ROCHON, J ;
FEDORAK, RN ;
IRVINE, EJ ;
WILD, G ;
SUTHERLAND, L ;
STEINHART, AH ;
GREENBERG, GR ;
GILLIES, R ;
HOPKINS, M ;
HANAUER, SB ;
MCDONALD, JWD .
NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (05) :292-297
[9]   Methotrexate Is Not Superior to Placebo in Maintaining Steroid-Free Response or Remission in Ulcerative Colitis [J].
Herfarth, Hans ;
Barnes, Edward L. ;
Valentine, John F. ;
Hanson, John ;
Higgins, Peter D. R. ;
Isaacs, Kim L. ;
Jackson, Susan ;
Osterman, Mark T. ;
Anton, Kristen ;
Ivanova, Anastasia ;
Long, Millie D. ;
Martin, Christopher ;
Sandler, Robert S. ;
Abraham, Bincy ;
Cross, Raymond K. ;
Dryden, Gerald ;
Fischer, Monika ;
Harlan, William ;
Levy, Campbell ;
McCabe, Robert ;
Polyak, Steven ;
Saha, Sumona ;
Williams, Emmanuelle ;
Yajnik, Vijay ;
Serrano, Jose ;
Sands, Bruce E. ;
Lewis, James D. .
GASTROENTEROLOGY, 2018, 155 (04) :1098-+
[10]   Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study [J].
Kennedy, Nicholas A. ;
Heap, Graham A. ;
Green, Harry D. ;
Hamilton, Benjamin ;
Bewshea, Claire ;
Walker, Gareth J. ;
Thomas, Amanda ;
Nice, Rachel ;
Perry, Mandy H. ;
Bouri, Sonia ;
Chanchlani, Neil ;
Heerasing, Neel M. ;
Hendy, Peter ;
Lin, Simeng ;
Gaya, Daniel R. ;
Cummings, J. R. Fraser ;
Selinger, Christian P. ;
Lees, Charlie W. ;
Hart, Ailsa L. ;
Parkes, Miles ;
Sebastian, Shaji ;
Mansfield, John C. ;
Irving, Peter M. ;
Lindsay, James ;
Russell, Richard K. ;
McDonald, Timothy J. ;
McGovern, Dermot ;
Goodhand, James R. ;
Ahmad, Tariq .
LANCET GASTROENTEROLOGY & HEPATOLOGY, 2019, 4 (05) :341-353